Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Lopez-Salazar, M.B. (María Begoña) | es_ES |
dc.creator | Gonzalez, A. (Arantxa) | es_ES |
dc.creator | Querejeta, R. (Ramón) | es_ES |
dc.creator | Larman, M. (Mariano) | es_ES |
dc.creator | Rabago, G. (Gregorio) | es_ES |
dc.creator | Diez-Martinez, J. (Javier) | es_ES |
dc.date.accessioned | 2014-05-30T12:11:19Z | - |
dc.date.available | 2014-05-30T12:11:19Z | - |
dc.date.issued | 2014 | es_ES |
dc.identifier.citation | López-Salazar, M. ; González-Miqueo, A. ; Querejeta, R.; Larman, M.; Rabago-Juan Aracil, G.; Díez, J. ""Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure "" Hypertension 2014;63:483-489 | - |
dc.identifier.issn | 0194-911X | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/35967 | - |
dc.description.abstract | Cardiotrophin-1 has been shown to be profibrogenic in experimental models. The aim of this study was to analyze whether cardiotrophin-1 is associated with left ventricular end-diastolic stress and myocardial fibrosis in hypertensive patients with heart failure. Endomyocardial biopsies from patients (n=31) and necropsies from 7 control subjects were studied. Myocardial cardiotrophin-1 protein and mRNA and the fraction of myocardial volume occupied by collagen were increased in patients compared with controls ( P <0.001). Cardiotrophin-1 overexpression in patients was localized in cardiomyocytes. Cardiotrophin-1 protein was correlated with collagen type I and III mRNAs ( r =0.653, P <0.001; r =0.541, P <0.01) and proteins ( r =0.588, P <0.001; r =0.556, P <0.005) in all subjects and with left ventricular end-diastolic wall stress ( r =0.450; P <0.05) in patients. Plasma cardiotrophin-1 and N-terminal pro-brain natriuretic peptide and serum biomarkers of myocardial fibrosis (carboxy-terminal propeptide of procollagen type I and amino-terminal propeptide of procollagen type III) were increased ( P <0.001) in patients compared with controls. Plasma cardiotrophin-1 was correlated with N-terminal pro-brain natriuretic peptide ( r =0.386; P <0.005), carboxy- terminal propeptide of procollagen type I ( r =0.550; P <0.001), and amino-terminal propeptide of procollagen type III ( r =0.267; P <0.05) in all subjects. In vitro, cardiotrophin-1 stimulated the differentiation of human cardiac fibroblast to myofibroblasts ( P <0.05) and the expression of procollagen type I ( P <0.05) and III ( P <0.01) mRNAs. These findings show that an excess of cardiotrophin-1 is associated with increased collagen in the myocardium of hypertensive patients with heart failure. It is proposed that exaggerated cardiomyocyte production of cardiotrophin-1 in response to increased left ventricular end-diastolic stress may contribute to fibrosis through stimulation of fibroblasts in heart failure of hypertensive origin | en_EN |
dc.language.iso | eng | en_EN |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/305507 | - |
dc.rights | info:eu-repo/semantics/openAccess | en_EN |
dc.subject | Cardiotrophin I | en_EN |
dc.subject | Collagen | en_EN |
dc.subject | Fibrosis | en_EN |
dc.subject | Heart failure | en_EN |
dc.title | Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:eu-repo/semantics/article | en_EN |
dc.publisher.place | HYPERTENSION633483 - 489 | es_ES |
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