Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Mirabello, L. (Lisa) | - |
dc.creator | Pfeiffer, R. (Ruth) | - |
dc.creator | Murphy, G. (Gwen) | - |
dc.creator | Daw, N.C. (Najat C.) | - |
dc.creator | Patiño-García, A. (Ana) | - |
dc.creator | Troisi, R.J. (Rebecca J.) | - |
dc.creator | Hoover, R.N. (Robert N.) | - |
dc.creator | Douglass, C. (Chester) | - |
dc.creator | Schüz, J. (Joachim) | - |
dc.creator | Craft, A.W. (Alan W.) | - |
dc.creator | Savage, S.A. (Sharon A.) | - |
dc.date.accessioned | 2014-07-15T08:38:57Z | - |
dc.date.available | 2014-07-15T08:38:57Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Mirabello L, Pfeiffer R, Murphy G, Daw NC, Patiño-Garcia A, Troisi RJ, et al. Height at diagnosis and birth-weight as risk factors for osteosarcoma. Cancer Causes Control. 2011 Jun;22(6):899-908. | es_ES |
dc.identifier.issn | 0957-5243 | - |
dc.identifier.uri | https://hdl.handle.net/10171/36155 | - |
dc.description.abstract | OBJECTIVES: Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma. METHODS: Patient data from seven studies of height and three of birth-weight were obtained, resulting in 1,067 cases with height and 434 cases with birth-weight data. We compared cases to the 2000 US National Center for Health Statistics Growth Charts by simulating 1,000 age- and gender-matched controls per case. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between height or birth-weight and risk of osteosarcoma for each study were estimated using logistic regression. All of the case data were combined for an aggregate analysis. RESULTS: Compared to average birth-weight subjects (2,665-4,045 g), individuals with high birth-weight (≥ 4,046 g) had an increased osteosarcoma risk (OR 1.35, 95% CI 1.01-1.79). Taller than average (51st - 89th percentile) and very tall individuals (≥ 90th percentile) had an increased risk of osteosarcoma (OR 1.35, 95% CI 1.18-1.54 and OR 2.60, 95% CI 2.19-3.07, respectively; P (trend) < 0.0001). CONCLUSIONS: This is the largest analysis of height at diagnosis and birth-weight in relation to osteosarcoma. It suggests that rapid bone growth during puberty and in utero contributes to OS etiology. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Osteosarcoma | es_ES |
dc.subject | Height | es_ES |
dc.subject | Birth-weight | es_ES |
dc.subject | Meta-analysis | es_ES |
dc.subject | Epidemiology | es_ES |
dc.title | Height at diagnosis and birth-weight as risk factors for osteosarcoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1007/s10552-011-9763-2 | es_ES |
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