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dc.creatorGutierrez, C. (Cristina)-
dc.creatorRodriguez, J. (Javier)-
dc.creatorPatiño-García, A. (Ana)-
dc.creatorGarcia-Foncillas, J. (Jesús)-
dc.creatorSalgado, J. (Josefa)-
dc.date.accessioned2014-07-15T09:37:27Z-
dc.date.available2014-07-15T09:37:27Z-
dc.date.issued2013-
dc.identifier.citationGutiérrez C, Rodriguez J, Patiño-García A, García-Foncillas J, Salgado J. KRAS mutational status analysis of peripheral blood isolated circulating tumor cells in metastatic colorectal patients. Oncol Lett. 2013 Nov;6(5):1343-1345.es_ES
dc.identifier.issn1792-1074-
dc.identifier.urihttp://hdl.handle.net/10171/36157-
dc.description.abstractThe present study describes an optimized method for isolating peripheral blood circulating tumor cells (CTCs) and performing KRAS mutation analysis. The approach combines isolation of peripheral blood mononuclear cells and immunomagnetic labeling with CD45 and CD326 human microbeads with KRAS analysis performed with a Therascreen KRAS kit by quantitative PCR. KRAS mutations were detected in the CTCs of patients with metastatic colorectal cancer (mCRC). CTCs may represent an alternative to invasive procedures and their analysis may be representative of the current disease status of the patient. This proposed analysis may be performed in a daily clinical practice.es_ES
dc.language.isoenges_ES
dc.publisherSpandidoses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectKRAS genees_ES
dc.subjectCirculating tumor cellses_ES
dc.subjectInmunomagnetic labelinges_ES
dc.subjectMetastatic colorectal canceres_ES
dc.subjectPeripheral bloodes_ES
dc.titleKRAS mutational status analysis of peripheral blood isolated circulating tumor cells in metastatic colorectal patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3892/ol.2013.1544es_ES

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