Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Elizalde, M. (María) | es_ES |
dc.creator | Raquel | es_ES |
dc.creator | Azkona, M.T. (María Teresa) | es_ES |
dc.creator | Latasa, M.U. (María Ujué) | es_ES |
dc.creator | Goñi, S. (Saioa) | es_ES |
dc.creator | García-Irigoyen, O. (Oihane) | es_ES |
dc.creator | Uriarte, I. (Iker) | es_ES |
dc.creator | Segura, V. (Víctor) | es_ES |
dc.creator | Collantes, M. (María) | es_ES |
dc.creator | Scala, M. (Marianna) Di | es_ES |
dc.creator | Lujambio, A. (Amaya) | es_ES |
dc.creator | Prieto, J. (Jesús) | es_ES |
dc.creator | Avila, M.A. (Matías Antonio) | es_ES |
dc.creator | Berasain, C. (Carmen) | es_ES |
dc.date.accessioned | 2014-07-15T12:01:01Z | - |
dc.date.available | 2014-07-15T12:01:01Z | - |
dc.date.issued | 2014 | es_ES |
dc.identifier.citation | Elizalde, M.; Urtasun, R. ; Azkona, M.; Latasa, M.; Goñi, S. ; García-Irigoyen, O.; Uriarte, I.; Segura, V. ; Collantes, M. ; Di-Scala, M. ; Lujambio, A. ; Prieto, J.; Ávila, M. ; Berasain, C. (Carmen). Splicing regulator SLU7 is essential for maintaining liver homeostasis. The Journal of Clinical Investigation, 2014, vol. 24, n.7, pp. 2909-2920 | es_ES |
dc.identifier.issn | 0021-9738 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/36167 | - |
dc.description.abstract | A precise equilibrium between cellular differentiation and proliferation is fundamental for tissue homeostasis. Maintaining this balance is particularly important for the liver, a highly differentiated organ with systemic metabolic functions that is endowed with unparalleled regenerative potential. Carcinogenesis in the liver develops as the result of hepatocellular de-differentiation and uncontrolled proliferation. Here, we identified SLU7, which encodes a pre-mRNA splicing regulator that is inhibited in hepatocarcinoma, as a pivotal gene for hepatocellular homeostasis. SLU7 knockdown in human liver cells and mouse liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern. Additionally, loss of SLU7 also increased hepatocellular proliferation and induced a switch to a tumor-like glycolytic phenotype. Slu7 governed the splicing and/or expression of multiple genes essential for hepatocellular differentiation, including serine/arginine-rich splicing factor 3 (Srsf3) and hepatocyte nuclear factor 4α (Hnf4α), and was critical for cAMP-regulated gene transcription. Together, out data indicate that SLU7 is central regulator of hepatocyte identity and quiescence. | en_EN |
dc.language.iso | eng | en_EN |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.title | Splicing regulator SLU7 is essential for maintaining liver homeostasis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.publisher.place | JOURNAL OF CLINICAL INVESTIGATION12472909-2920 | es_ES |
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