Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.advisorAzcona-San-Julian, M.C. (María Cristina)-
dc.contributor.advisorMarti, A. (Amelia)-
dc.creatorMoleres, A. (Adriana)-
dc.identifier.citationMOLERES VILLARES, Adriana. “Influencia de alteraciones genéticas y epigenéticas sobre la obesidad y la pérdida de peso en niños y adolescentes españoles”. Marti del Moral, A. y Azcona-Sanjulián, M.C. (dirs.). Tesis doctoral. Universidad de Navarra, Pamplona, 2012es_ES
dc.description.abstractThis Doctoral Thesis reports the role of genetic and epigenetic variations on obesity risk, and weight loss response in three different populations of Spanish children and adolescents between 6 and 18 years old. The first manuscript examines the association of the -174 G/C SNP of the IL-6 gene and adiposity and inflammatory markers. For this purpose, 504 Spanish adolescents from the AVENA study were genotyped for the SNP, body measurements were taken and blood samples were collected. The association between body fat mass and some plasma markers was influenced by the presence of this polymorphism. Adolescents carrying the C allele showed higher values of lipoprotein(a) , C-reactive protein and triglycerides as their body fat mass increases. In the second study, the effect of the rs9939609 of the FTO on obesity risk was studied. The trial involved 354 children and adolescents (GENOI study) following a case-control study. In this study, we confirmed the association between the FTO SNP and obesity risk. Interestingly, an interaction between SFA consumption on the effect and the polymorphism on obesity risk was evidenced. The third research article evaluates the contribution of 9 SNPs on anthropometric and biochemical parameters before and after a weight loss intervention programme in 168 adolescents participating in the EVASYON programme. A genetic predisposition score (GPS) calculated from these polymorphisms revealed a significant effect size on body composition both at baseline and after 10 weeks of treatment. Adolescents with a lower GPS seemed to have greater benefit of weight loss after the intervention. Finally, the fourth publication explored baseline changes in DNA methylation that could be associated with a better weight loss response after an intervention in obese/overweight adolescents. A methylation score calculated from differentially methylated genes was associated with changes in anthropometric parameters after treatment. In addition, after a methylation array, five regions showed differential methylation levels between high and low responders to the intervention. In summary, data from the current Doctoral Thesis contribute to provide evidence of the influence that some genetic variants and epigenetic alterations could have on obesity and the weight loss response.es_ES
dc.publisherServicio de Publicaciones de la Universidad de Navarraes_ES
dc.subjectMaterias Investigacion::Farmaciaes_ES
dc.subjectMultidisciplinary interventiones_ES
dc.subjectGenetic variantses_ES
dc.titleInfluencia de alteraciones genéticas y epigenéticas sobre la obesidad y la pérdida de peso en niños y adolescentres españoleses_ES
dc.title.alternativeInfluence of genetic and epigenetic modifications on obesity and weight loss in Spanish children and adolescentses_ES

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