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dc.creatorPujante, P. (P.)-
dc.creatorAbreu, C. (Cristina)-
dc.creatorMoreno-Arribas, J. (José)-
dc.creatorBarrero-Alegria, E. (Eduardo)-
dc.creatorAzcarate, P.M. (Pedro María)-
dc.creatorCampo, A. (Arantza)-
dc.creatorUrrestarazu, E. (Elena)-
dc.creatorSilva, C. (Camilo)-
dc.creatorGil-Maria, J. (Jesús)-
dc.creatorTebar, J. (Javier)-
dc.creatorFrühbeck, G. (Gema)-
dc.creatorSalvador, J. (Javier)-
dc.date.accessioned2014-08-19T12:07:36Z-
dc.date.available2014-08-19T12:07:36Z-
dc.date.issued2013-
dc.identifier.citationPujante P, Abreu C, Moreno J, Barrero EA, Azcarate P, Campo A, et al. Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity. J Clin Sleep Med. 2013 Nov 15;9(11):1165-1171es_ES
dc.identifier.issn1550-9389-
dc.identifier.urihttps://hdl.handle.net/10171/36333-
dc.description.abstractOBJECTIVE: To evaluate the relation between obstructive sleep apnea (OSA) and left ventricular mass (LVM) in morbid obesity and the influence of gender, menopausal status, anthropometry, body composition, hypertension, and other cardiovascular risk factors in this relationship. DESIGN: Cross-sectional descriptive study. METHODS: Polysomnographic and echocardiographic studies were performed in a cohort of 242 patients (86 men, 100 premenopausal (PreM) and 56 postmenopausal (PostM) women), with grade II obesity and above (BMI: 43.7 ± 0.4 kg/m(2)) to investigate OSA and LVM respectively. Anthropometry, body composition, glucose tolerance, and blood pressure were also recorded. RESULTS: OSA to different degrees was diagnosed in 76.2% of the patients (n: 166), its prevalence being 90.9% (n: 70) for men, and 76% (n: 38) and 63.8% (n: 58) for PostM and PreM women, respectively (p < 0.01). LVM excess was greatest for PostM women (90.2%), followed by men (81.9%) and PreM females (69.6%) (p < 0.01). LVM values increased in accordance to OSA severity (absence, 193.7 ± 6.9 g; mild, 192.6 ± 7.8 g; moderate, 240.5 ± 12.5 g; severe, 273.6 ± 14.6 g; p < 0.01). LVM magnitude correlated with the menopausal state, age, central adiposity, hypertension (HT), type 2 diabetes (DM), desaturation index (DI), and apnea-hypopnea index (AHI) (r = 0.41; p < 0.01). The relationship between LVM and AHI persisted in the multivariate analysis (β = 0.25; p < 0.05) after adjusting for age, gender, menopausal state, BMI, waist circumference, neck circumference, DI, fasting plasma glucose, DM, and HT. But if tobacco habits are included, the statistical difference disappears (β = 0.22; p = 0.06). CONCLUSIONS: Morbid obesity is frequently associated with abnormal LVM, particularly in patients with OSA; this association is independent of HT, BMI, body composition, and other clinical factors, supporting a direct role of OSA on LVM in morbid obesity. This suggests that OSA and LVM might be taken as predictors of the cardiovascular risk in these patients. KEYWORDS: Sleep apnea; apnea-hypopnea index; left ventricular mass; morbid obesityes_ES
dc.language.isoenges_ES
dc.publisherAmerican Academy of Sleep Medicinees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectSleep apneaes_ES
dc.subjectApnea-hypopnea indexes_ES
dc.subjectLeft ventricular masses_ES
dc.subjectMorbid obesityes_ES
dc.titleObstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttp://dx.doi.org/10.5664/jcsm.3160es_ES

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