Full metadata record
DC FieldValueLanguage
dc.creatorSavage, S.A. (Sharon A.)-
dc.creatorMirabello, L. (Lisa)-
dc.creatorWang, Z. (Zhaoming)-
dc.creatorGastier-Foster, J.M. (Julie M.)-
dc.creatorGorlick, R. (Richard)-
dc.creatorKhanna, C. (Chand)-
dc.creatorFlanagan, A.M. (Adrienne M.)-
dc.creatorTirabosco, R. (Roberto)-
dc.creatorAndrulis, I.L. (Irene L.)-
dc.creatorWunder, J.S. (Jay S.)-
dc.creatorGokgoz, N. (Nalan)-
dc.creatorPatiño-García, A. (Ana)-
dc.creatorSierrasesumaga, L. (Luis)-
dc.creatorLecanda, F. (Fernando)-
dc.creatorKurucu, N. (Nilgün)-
dc.creatorIlhan, I.E. (Inci Ergurhan)-
dc.creatorSari, N. (Neriman)-
dc.creatorSerra, M. (Massimo)-
dc.creatorHattinger, C. (Claudia)-
dc.creatorPicci, P. (Piero)-
dc.creatorSpector, L. (Logan)-
dc.creatorBarkauskas, D.A. (Donald A.)-
dc.creatorMarina, N. (Neyssa)-
dc.creatorCaminada-de-Toledo, S.R. (Silvia Regina)-
dc.creatorPetrilli, A.S. (Antonio S.)-
dc.creatorAmary, M.F. (María Fernanda)-
dc.creatorHalai, D. (Dina)-
dc.creatorThomas, D.M. (David M.)-
dc.creatorDouglass, C. (Chester)-
dc.creatorMeltzer, P.S. (Paul S.)-
dc.creatorJacobs, K. (Kevin)-
dc.creatorChung, C.C. (Charles C.)-
dc.creatorBerndt, S.I. (Sonja I.)-
dc.creatorPurdue, M.P. (Mark P.)-
dc.creatorCaporaso, N.E. (Neil E.)-
dc.creatorTucker, M. (Margaret)-
dc.creatorRothman, N. (Nathaniel)-
dc.creatorLandi, M.T. (María Teresa)-
dc.creatorSilverman, D.T. (Debra T.)-
dc.creatorKraft, P. (Peter)-
dc.creatorHunter, D.J. (David J.)-
dc.creatorMalats, N. (Nuria)-
dc.creatorKogevinas, M. (Manolis)-
dc.creatorWacholder, S. (Sholom)-
dc.creatorTroisi, R. (Rebecca)-
dc.creatorHelman, L. (Lee)-
dc.creatorFraumeni, J.F. (Joseph F.)-
dc.creatorYeager, M. (Meredith)-
dc.creatorHoover, R.N. (Robert N.)-
dc.creatorChanock, S.J. (Stephen J.)-
dc.date.accessioned2014-08-30T17:26:57Z-
dc.date.available2014-08-30T17:26:57Z-
dc.date.issued2013-07-
dc.identifier.citationSavage SA, Mirabello L, Wang Z, Gastier-Foster JM, Gorlick R, Khanna C, et al. Genome-wide association study identifies two susceptibility loci for osteosarcoma. Nat Genet. 2013 Jul;45(7):799-803es_ES
dc.identifier.issn1061-4036-
dc.identifier.urihttp://hdl.handle.net/10171/36418-
dc.description.abstractOsteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10⁻⁹) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relationinfo:eu-repo/grantAgreement/NIH/FP7/3U10CA098543-03S1 - 3U24CA114766-05S2-
dc.relationinfo:eu-repo/grantAgreement/WT/FP7/-
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectOsteosarcomaes_ES
dc.subjectPolymorphism, single nucleotidees_ES
dc.subjectEuropean continental ancestry groupes_ES
dc.subjectBone neoplasmses_ES
dc.titleGenome-wide association study identifies two susceptibility loci for osteosarcomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1038/ng.2645es_ES

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