Experimental heart preservation for 24 hours: benefits of PGE1 in a nonpulsatile coronary perfusion solution

Abstract

The increase in activity of centers with cardiac transplant programs has been limited because of the unavailability of high quality donor organs. Nonpulsatile coronary perfusion (NPCP) with hypothermia has allowed long-term cardiac preservation in various experimental models.1-4 This experiment was designed to study the effects of PGE1 in an experimental NPCP.