Full metadata record
DC Field | Value | Language |
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dc.creator | Lorente, L. (Leonardo) | - |
dc.creator | Martin, M.M. (María M.) | - |
dc.creator | Lopez, P. (Patricia) | - |
dc.creator | Ramos, L. (Luis) | - |
dc.creator | Blanquer, J. (José) | - |
dc.creator | Caceres, J.J. (Juan J.) | - |
dc.creator | Sole-Violan, J. (Jordi) | - |
dc.creator | Solera, J. (Jorge) | - |
dc.creator | Cabrera, J. (Judith) | - |
dc.creator | Argueso, M. (Mónica) | - |
dc.creator | Raquel | - |
dc.creator | Mora, M.L. (María L.) | - |
dc.creator | Lubillo, S. (Santiago) | - |
dc.creator | Jimenez, A. (Alejandro) | - |
dc.creator | Borreguero-Leon, J.M. (Juan María) | - |
dc.creator | Gonzalez, A. (Agustín) | - |
dc.creator | Orbe, J. (Josune) | - |
dc.creator | Rodriguez, J.A. (José Antonio) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.date.accessioned | 2014-09-23T16:42:23Z | - |
dc.date.available | 2014-09-23T16:42:23Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | Lorente L, Martín MM, López P, Ramos L, Blanquer J, Cáceres JJ, et al. Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury. PLoS One. 2014 Apr 11;9(4):e94370. | es_ES |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10171/36694 | - |
dc.description.abstract | OBJECTIVE: Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) play a role in neuroinflammation after brain trauma injury (TBI). Previous studies with small sample size have reported higher circulating MMP-2 and MMP-9 levels in patients with TBI, but no association between those levels and mortality. Thus, the aim of this study was to determine whether serum TIMP-1 and MMP-9 levels are associated with mortality in patients with severe TBI. METHODS: This was a multicenter, observational and prospective study carried out in six Spanish Intensive Care Units. Patients with severe TBI defined as Glasgow Coma Scale (GCS) lower than 9 were included, while those with Injury Severity Score (ISS) in non-cranial aspects higher than 9 were excluded. Serum levels of TIMP-1, MMP-9 and tumor necrosis factor (TNF)-alpha, and plasma levels of tissue factor (TF) and plasminogen activator inhibitor (PAI)-1 plasma were measured in 100 patients with severe TBI at admission. Endpoint was 30-day mortality. RESULTS: Non-surviving TBI patients (n = 27) showed higher serum TIMP-1 levels than survivor ones (n = 73). We did not find differences in MMP-9 serum levels. Logistic regression analysis showed that serum TIMP-1 levels were associated 30-day mortality (OR = 1.01; 95% CI = 1.001-1.013; P = 0.03). Survival analysis showed that patients with serum TIMP-1 higher than 220 ng/mL presented increased 30-day mortality than patients with lower levels (Chi-square = 5.50; P = 0.02). The area under the curve (AUC) for TIMP-1 as predictor of 30-day mortality was 0.73 (95% CI = 0.624-0.844; P<0.001). An association between TIMP-1 levels and APACHE-II score, TNF- alpha and TF was found. CONCLUSIONS: The most relevant and new findings of our study, the largest series reporting data on TIMP-1 and MMP-9 levels in patients with severe TBI, were that serum TIMP-1 levels were associated with TBI mortality and could be used as a prognostic biomarker of mortality in TBI patients. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Brain trauma injury | es_ES |
dc.subject | Neuroinflammation | es_ES |
dc.subject | Matrix metalloproteinases (MMPs) | es_ES |
dc.subject | Tissue inhibitors of matrix metalloproteinases (TIMPs) | es_ES |
dc.subject | MMP-2 | es_ES |
dc.subject | MMP-9 | es_ES |
dc.subject | TIMP-1 | es_ES |
dc.subject | Mortality | es_ES |
dc.title | Association between serum tissue inhibitor of matrix metalloproteinase-1 levels and mortality in patients with severe brain trauma injury | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0094370 | es_ES |
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