Alcohol intake Depression Cohort analysis Mediterranean population
Fecha de publicación:
Gea A, Martínez-González MA, Toledo E, Sanchez-Villegas A, Bes-Rastrollo M, Nuñez-Córdoba JM, et al. A longitudinal assessment of alcohol intake and incident depression: the sun project. BMC Public Health. 2012 Nov 7;12:954.
Background: Longitudinal studies assessing the long-term association between alcohol intake and depression are
scarce. The type of beverage may also be important. Therefore we aimed to prospectively evaluate the influence of
alcohol intake on incident depression in a Mediterranean cohort.
Methods: We assessed 13,619 university graduates (mean age: 38 years, 42% men) participating in a Spanish
prospective epidemiological cohort (the SUN Project), initially free of depression. They were recruited between
1999–2008 and biennially followed-up during 2001–2010. At baseline, a 136-item validated food–frequency
questionnaire was used to assess alcohol intake. Wine was the preferred beverage. Participants were classified as
incident cases of depression if they reported a new clinical diagnosis of depression by a physician and/or initiated
the use of antidepressant drugs. Cox regression and restricted cubic splines analyses were performed over 82,926
Results: Only among women, an U-shaped relationship between total alcohol intake and depression risk was found
(P=0.01). Moderate alcohol intake (5–15 g/day) was associated with lower risk (Hazard Ratio: 0.62; 95% Confidence
Interval: 0.43-0.89). No association was apparent for higher intakes of alcohol or for any specific type of alcoholic
Conclusions: Moderate alcohol intake might protect against depression among women. Further confirmatory
studies are needed.