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dc.creatorGonzalez-Muniesa, P. (Pedro)-
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)-
dc.creatorCampión-Zabalza, J. (Javier)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.date.accessioned2014-11-25T14:01:19Z-
dc.date.available2014-11-25T14:01:19Z-
dc.date.issued2006-
dc.identifier.citationGonzález-Muniesa P, Milagro FI, Campión J, Martínez JA. Reduction in energy efficiency induced by expression of the uncoupling protein, UCPl, in mouse liver mitochondria. Int J Mol Med. 2006 Apr;17(4):591-597es_ES
dc.identifier.issn1107-3756-
dc.identifier.urihttp://hdl.handle.net/10171/37102-
dc.description.abstractUncoupling Protein l (UCPl) is an inner mito­ chondrial membrane protein, uniquely expressed in brown adipocytes, which uncouples the mitochondrial respiration impairing ATP production and energy efficiency. The aim of the present study was to express UCPl in liver mitochondria using a non-viral system in order to affect energy utilization. The effect of ectopic protein expression on liver energy metabolism, which was evaluated 42 h after DNA transfer, showed that mitochondria expressing UCPl presented decreased ATP production, lasted more time in membrane potential state 3, and consumed more molecular oxygen to produce the same amount of ATP than the control group. In summary, the successful functionality of the mitochondrial protein, UCPl, after hydrodynamic delivery is a novel and significant finding. This approach could be useful to ectopic­ ally express mitochondrial proteins and, in this particular case, to manage metabolic disorders related to energy efficiency and expenditure, such as obesity.es_ES
dc.language.isoenges_ES
dc.publisherSpandidos Publicationses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectEnergyes_ES
dc.subjectMetabolismes_ES
dc.subjectUncoupling protein-1es_ES
dc.subjectGene deliveryes_ES
dc.subjectHydrodynamicses_ES
dc.subjectATPes_ES
dc.subjectUCPes_ES
dc.titleReduction in energy efficiency induced by expression of the uncoupling protein, UCPl, in mouse liver mitochondriaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3892/ijmm.17.4.591es_ES

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