Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Berasain, C. (Carmen) | - |
dc.contributor.advisor | Avila, M.A. (Matías Antonio) | - |
dc.creator | Elizalde, M. (María) | - |
dc.date.accessioned | 2014-12-09T17:03:39Z | - |
dc.date.available | 2014-12-09T17:03:39Z | - |
dc.date.issued | 2014 | - |
dc.date.submitted | 2014-06-24 | - |
dc.identifier.citation | ELIZALDE, M. “Estudio del papel fisiopatológico de Slu7 en el hígado”. Berasain, C. y Avila, M. (dirs). Tesis doctoral. Universidad de Navarra, Pamplona, 2014 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/37155 | - |
dc.description.abstract | A precise equilibrium between cellular differentiation and proliferation is fundamental for tissue homeostasis. Maintaining this balance is particularly important for the liver, a highly differentiated organ with systemic metabolic functions that is endowed with unparalleled regenerative potential. Carcinogenesis in the liver develops as the result of hepatocellular de-differentiation and uncontrolled proliferation. Here, we identified SLU7, which encodes a pre-mRNA splicing regulator that is inhibited in hepatocarcinoma, as a pivotal gene for hepatocellular homeostasis. SLU7 knockdown in human liver cells and mouse liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern. Additionally, loss of SLU7 also increased hepatocellular proliferation and induced a switch to a tumor-like glycolytic phenotype. Slu7 governed the splicing and/or expression of multiple genes essential for hepatocellular differentiation, including serine/arginine-rich splicing factor 3 (Srsf3) and hepatocyte nuclear factor 4α (Hnf4α), and was critical for cAMP-regulated gene transcription. Together, out data indicate that SLU7 is central regulator of hepatocyte identity and quiescence. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Servicio de Publicaciones de la Universidad de Navarra | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Procesos metabólicos | es_ES |
dc.subject | Bioquímica molecular | es_ES |
dc.subject | Metabolismo humano | es_ES |
dc.subject | Oncología clínica | es_ES |
dc.subject | Materias Investigacion::Ciencias de la vida | es_ES |
dc.title | Estudio del papel fisiopatológico de Slu7 en el hígado | es_ES |
dc.type | info:eu-repo/semantics/doctoralThesis | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.