Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Marti-del-Moral, A. (Amelia) | - |
dc.contributor.advisor | Martinez, J.A. (José Alfredo) | - |
dc.creator | Rendo-Urteaga, T. (Tara) | - |
dc.date.accessioned | 2015-01-29T17:16:13Z | - |
dc.date.available | 2015-01-29T17:16:13Z | - |
dc.date.issued | 2015 | - |
dc.date.submitted | 2012-12-12 | - |
dc.identifier.citation | RENDO URTEAGA, Tara. “Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso”. Martí, A. y Martínez, A. (dirs.). Tesis doctoral. Universidad de Navarra, Pamplona, 2012 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/37384 | - |
dc.description.abstract | The increasing prevalence of childhood obesity makes necessary to intensify obesity treatment. A successful weight loss programme in overweight and obese children and adolescents should be accompanied by a general metabolic improvement and a reduction in several cardiovascular risk factors. The aim of this study was to evaluate the effect of a 10-week intervention program, based on a moderate calorie restriction on metabolic and oxidative stress markers and gene expression profile in peripheral blood mononuclear cells (PBMC) from obese children. For this purpose, forty-four overweight/obese children (mean age 11.5 years; 50% males) were enrolled in a 10-week weight loss programme. Subjects were dichotomized by the median of Body Mass Index-Standard Deviation Score (BMI-SDS) change as high (HR) and low responders (LR) at the end of the weight loss programme. These results suggest that a lower decrease in dietary total antioxidant capacity (TAC) after the intervention may predict a greater weight loss in obese children with a good response to the diet. Furthermore, a better serum antioxidant-oxidant balance before a weight loss treatment could predict a better weight loss response. On the other hand, we showed, for the first time, a reduction in serum cardiotrophin-1 levels after a weight loss programme and that this decrease in cardiotrophin-1 was strongly associated with lower cholesterol levels in overweight/obese children. Finally, the study confirms that PBMC gene expression changes in obese boys may help to understand the weight loss response. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Servicio de Publicaciones de la Universidad de Navarra | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | * |
dc.subject | Ciencias de la nutrición | es_ES |
dc.subject | Población infantil | es_ES |
dc.subject | Materias Investigacion::Farmacia | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Nutrición y dietética | es_ES |
dc.subject | Niños | es_ES |
dc.subject | Genética humana | es_ES |
dc.title | Perfil metabólico y transcriptómico en población infantil obesa tras una intervención nutricional para la pérdida de peso | es_ES |
dc.type | info:eu-repo/semantics/doctoralThesis | es_ES |
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