Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity

Seidensticker, M. (Max); Seidensticker, R. (Ricarda); Damn, R. (Robert); Mohnike, K. (Konrad); Pech, M. (Maciej); Sangro, B. (Bruno); Hass, P. (Peter); Wust, P. (Peter); Kropf, S. (Siegfried); Gademann, G. (Günther); Ricke, J. (Jeans)

Keywords:

Liver
Pentoxifylline and ursodeoxycholic acid

Issue Date:

2014

Publisher:

Public Library of Science

ISSN:

1932-6203

Editorial note:

Attribution 4.0 International (CC BY 4.0)

Citation:

Seidensticker M, Seidensticker R, Damm R, Mohnike K, Pech M, et al. Prospective Randomized Trial of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid for Prevention of Radiation-Induced Liver Toxicity. PLoS ONE 2014;9(11): e112731.

Abstract

The post-therapeutic application of PTX, UDCA and low-dose LMWH significantly reduced the extent and incidence fRILI at 6 weeks after radiotherapy. The development of subsequent fRILI at 12 weeks (4 weeks after cessation of PTX, UDCA and LMWH during weeks 1-8) in the treatment group was comparable to the control group thus supporting the observation that the agents mitigated fRILI.

URI:

https://hdl.handle.net/10171/38240

DOI:

http://dx.doi.org/ 10.1371/journal.pone.0112731

Appears in Collections:

DA - CUN - Medicina interna - Artículos de revista

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