Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity
Keywords: 
Liver
Pentoxifylline and ursodeoxycholic acid
Issue Date: 
2014
Publisher: 
Public Library of Science
ISSN: 
1932-6203
Editorial note: 
Attribution 4.0 International (CC BY 4.0)
Citation: 
Seidensticker M, Seidensticker R, Damm R, Mohnike K, Pech M, et al. Prospective Randomized Trial of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid for Prevention of Radiation-Induced Liver Toxicity. PLoS ONE 2014;9(11): e112731.
Abstract
The post-therapeutic application of PTX, UDCA and low-dose LMWH significantly reduced the extent and incidence fRILI at 6 weeks after radiotherapy. The development of subsequent fRILI at 12 weeks (4 weeks after cessation of PTX, UDCA and LMWH during weeks 1-8) in the treatment group was comparable to the control group thus supporting the observation that the agents mitigated fRILI.

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