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dc.creatorAixalá, Jaime. El mistico serafin de la Menor Regular Clerencia, exaltado al sacratisimo trono de los altares ...-
dc.creatorSuarez-Amaran, L. (Lester)-
dc.creatorUsai, C. (Carla)-
dc.creatorGonzalez-Aseguinolaza, G. (Gloria)-
dc.date.accessioned2015-05-18T11:00:10Z-
dc.date.available2015-05-18T11:00:10Z-
dc.date.issued2015-
dc.identifier.citationAldabe R, Suárez-Amarán L, Usai C, González-Aseguinolaza G. Animal Models of Chronic Hepatitis Delta Virus Infection Host–Virus Immunologic Interactions. Pathogens. Feb 2015;4(1):46-65.es_ES
dc.identifier.issn2076-0817-
dc.identifier.urihttps://hdl.handle.net/10171/38345-
dc.description.abstractHepatitis delta virus (HDV) is a defective RNA virus that has an absolute requirement for a virus belonging to the hepadnaviridae family like hepatitis B virus (HBV) for its replication and formation of new virions. HDV infection is usually associated with a worsening of HBV-induced liver pathogenesis, which leads to more frequent cirrhosis, increased risk of hepatocellular carcinoma (HCC), and fulminant hepatitis. Importantly, no selective therapies are available for HDV infection. The mainstay of treatment for HDV infection is pegylated interferon alpha; however, response rates to this therapy are poor. A better knowledge of HDV–host cell interaction will help with the identification of novel therapeutic targets, which are urgently needed. Animal models like hepadnavirus-infected chimpanzees or the eastern woodchuck have been of great value for the characterization of HDV chronic infection. Recently, more practical animal models in which to perform a deeper study of host virus interactions and to evaluate new therapeutic strategies have been developed. Therefore, the main focus of this review is to discuss the current knowledge about HDV host interactions obtained from cell culture and animal models.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHepatitis delta viruses_ES
dc.subjectHDV animal modelses_ES
dc.subjectLiver damagees_ES
dc.subjectAntiviral treatmentes_ES
dc.subjectVaccineses_ES
dc.titleAnimal models of chronic hepatitis delta virus infection host–virus immunologic interactionses_ES
dc.typeArticuloes_ES
dc.identifier.doihttp://dx.doi.org/10.3390/pathogens4010046es_ES

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