Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Martinez-Climent, J.A. (José Ángel) | - |
dc.contributor.advisor | Robles, E.F. (Eloy Francisco) | - |
dc.creator | Mena-Varas, M. (María) | - |
dc.date.accessioned | 2016-01-21T11:24:45Z | - |
dc.date.available | 2016-01-21T11:24:45Z | - |
dc.date.issued | 2016 | - |
dc.date.submitted | 2015-09-21 | - |
dc.identifier.citation | MENA VARAS, María. “Role of homeobox NKX2-3 protein in marginal-zone B-cell lymphomagenesis using an in vivo mouse model”. Martínez-Clíment, José Ángel (dir.), Robles Cortés, Eloy Francisco (codir.). Tesis doctoral. Universidad de Navarra, Pamplona, 2015 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/39773 | - |
dc.description.abstract | NKX2 homeobox family proteins play a role in cancer development. Molecular cloning of a translocation t(10;14)(q24;q32) from a marginal-zone B-cell lymphoma revealed NKX2-3 as an IGH partner gene, leading to increased NKX2-3 expression with respect to B lymphocytes. NKX2-3 overexpression was also detected in tumor cells from a subset of patients with extranodal and splenic marginal-zone lymphomas, but not with other mature B-cell malignancies. While Nkx2-3 deficient mice exhibited atrophic spleens with absence of marginal-zone B cells, transgenic mice with expression of NKX2-3 in B cells showed progressive splenomegaly with marginal-zone expansion, and eventually developed tumors faithfully recapitulating the phenotype, cellular and molecular biology of human marginal-zone lymphomas. Mechanistically, NKX2-3 induced constitutive B-cell receptor (BCR) signaling by phosphorylating Lyn and Syk kinases. These molecules enhanced proliferation and eventually acquiring genomic rearrangements that triggered NF-κB and PI3K-AKT pathways to drive malignant transformation. This study implicates oncogenic NKX2-3 in marginal-zone lymphomagenesis, and provides a valid experimental mouse model for studying the biology and therapy of human lymphoma. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Biología molecular | es_ES |
dc.subject | Genética molecular | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud | es_ES |
dc.title | Role of homeobox NKX2-3 protein in marginal-zone B-cell lymphomagenesis using an in vivo mouse model | es_ES |
dc.type | info:eu-repo/semantics/doctoralThesis | es_ES |
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