Effects of α-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved
Palabras clave : 
Adipocytes
Lipid metabolism
Obesity
α-Lipoic acid
Nutrientes
Biología humana
Metabolismo energético
Biología celular
Fecha de publicación: 
2016
Fecha de la defensa: 
18-dic-2013
Cita: 
FERNÁNDEZ GALILEA, Marta. “Effects of α-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved”. Moreno Aliaga, María Jesús (dire.), Pérez Matute, Carmen Patricia (codir.). Tesis doctoral. Universidad de Navarra, Pamplona, 2013
Resumen
α-lipoic acid (5-(1,2-dithiolan-3-yl)-pentanoic acid) is a natural occurring compound which possesses antioxidant properties. Moreover, anti-obesity properties in both rodents and humans have been attributed to α-lipoic acid being adipose tissue a target for this compound. In this context, the present study has demonstrated the ability of α-LA to modulate lipid metabolism in both murine and human white adipocytes. Thus, α-LA: 1) Inhibits fatty acids uptake (through CD36 downregulation); 2) Reduces fatty acids esterification into triglycerides (through DGAT1 reduction); 3) Decreases de novo lipogenesis (induced by inhibition of FAS, SCD1 and ACC mediated by AMPK activation); 4) Stimulates lipolysis (mainly mediated by the phosphorylation of HSL through cAMP-mediated activation of PKA, probably through the inhibition of AdPLA and PGE2; 5) Increases fatty acid oxidation machinery (CPT1 and ACOX) in white adipocytes; 6) Promotes mitochondrial biogenesis by the activation of PGC-1α mediated by SIRT1 and AMPK activation; and 7) Induces a brown-like remodelling in white subcutaneous adipocytes from overweight/obese subjects. Taking together all of these facts suggest that α-LA remodels adipocyte metabolism towards oxidation rather than storage, and this could contribute to the anti-obesity properties of α-LA.

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Fichero: 
Tesis_MartaFernandezGalilea.pdf
Descripción: 
Tamaño: 
5,46 MB
Formato: 
Adobe PDF


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