Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Perez-Matute, P. (Patricia) | - |
dc.contributor.advisor | Moreno-Aliaga, M. J. (María Jesús) | - |
dc.creator | Fernandez-Galilea, M. (Marta) | - |
dc.date.accessioned | 2016-01-25T12:24:15Z | - |
dc.date.available | 2016-01-25T12:24:15Z | - |
dc.date.issued | 2016 | - |
dc.date.submitted | 2013-12-18 | - |
dc.identifier.citation | FERNÁNDEZ GALILEA, Marta. “Effects of α-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved”. Moreno Aliaga, María Jesús (dire.), Pérez Matute, Carmen Patricia (codir.). Tesis doctoral. Universidad de Navarra, Pamplona, 2013 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/39790 | - |
dc.description.abstract | α-lipoic acid (5-(1,2-dithiolan-3-yl)-pentanoic acid) is a natural occurring compound which possesses antioxidant properties. Moreover, anti-obesity properties in both rodents and humans have been attributed to α-lipoic acid being adipose tissue a target for this compound. In this context, the present study has demonstrated the ability of α-LA to modulate lipid metabolism in both murine and human white adipocytes. Thus, α-LA: 1) Inhibits fatty acids uptake (through CD36 downregulation); 2) Reduces fatty acids esterification into triglycerides (through DGAT1 reduction); 3) Decreases de novo lipogenesis (induced by inhibition of FAS, SCD1 and ACC mediated by AMPK activation); 4) Stimulates lipolysis (mainly mediated by the phosphorylation of HSL through cAMP-mediated activation of PKA, probably through the inhibition of AdPLA and PGE2; 5) Increases fatty acid oxidation machinery (CPT1 and ACOX) in white adipocytes; 6) Promotes mitochondrial biogenesis by the activation of PGC-1α mediated by SIRT1 and AMPK activation; and 7) Induces a brown-like remodelling in white subcutaneous adipocytes from overweight/obese subjects. Taking together all of these facts suggest that α-LA remodels adipocyte metabolism towards oxidation rather than storage, and this could contribute to the anti-obesity properties of α-LA. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Adipocytes | es_ES |
dc.subject | Lipid metabolism | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | α-Lipoic acid | es_ES |
dc.subject | Nutrientes | es_ES |
dc.subject | Biología humana | es_ES |
dc.subject | Metabolismo energético | es_ES |
dc.subject | Biología celular | es_ES |
dc.title | Effects of α-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved | es_ES |
dc.type | info:eu-repo/semantics/doctoralThesis | es_ES |
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