c-Jun N-terminal Kinase (JNK) signaling as a therapeutic target for Alzheimer’s disease
Keywords: 
Apoptosis
βamyloid
Tau
Kinase
Inhibitors
SP600125
D-JNKI1
Materias Investigacion::Ciencias de la Salud::Terapéutica
Issue Date: 
2016
Publisher: 
Frontiers Media
ISSN: 
1663-9812
Editorial note: 
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission
Note: 
Creative Commons Attribution License
Citation: 
Yarza R, Vela S, Solas M and Ramirez MJ. c-Jun N-terminal Kinase (JNK) signaling as a therapeutic target for Alzheimer’s disease. Front Pharmacol 2016;6:321
Abstract
C-Jun N-terminal (JNKs)are family of protein kinase that play a central role in stress signaling pathways implicated in gener expression, neuronal plasticity, regeneration, cell death, and regulation of dellular senescence. It has been shown that there is a JNK pathways activation after exposure to different stressing factors, including cytokines, growth factors, oxidative stress, unfolded protein responde signals or Aβ peptides. Altogether, JNKs have become a focus os creening strategies searching for new therapeutic approaches to diabetes, cancer or live diseases. In addition, activation of JNK has been identified as a key element responsable for the regulation os apoptosis signals and therefore, it is critical for pathological cell death associated with neurodegenerative diseases and, among them, with Alzheimer's disease (AD). In addition, in vitro and in vivo studiesb have reported alterations of JNK pathways potentially associated with pathogenesis and neuronal death in AD. JNK's, particulary JNK3, not only enhace Aβ production, moreover it plays a key role in the maduration and development of neurofibrillary tangles. This review aims to explains the rationale behind testing therapies based on inhibition of JNK signaling for AD in terms of current knowledge about the pathophysiology of the disease. Keeping in mind that JNK3 is specifically expressed in the brain and activated by stress-stimuli, it is possible to hypothesize that inhibition of JNK3 might be considered as a potential target for treating neurodegenerative mechanisms associated with AD.

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