Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
Palabras clave : 
Materias Investigacion::Ciencias de la Salud::Medicina preventiva
PREDIMED study
Long-term follow-up
Cardiovascular risk factors
Polyphenols in urine
Biomarker
Effects of Polyphenol
Fecha de publicación: 
2016
Editorial : 
Hindawi Publishing Corporation
ISSN: 
1942-0900
Nota de editorial: 
Copyright © 2016 Xiaohui Guo et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cita: 
Xiaohui G, Tresserra-Rimbau A, Estruch R, Martinez-Gonzalez MA, Medina-Remon A, Castañer O, et al. Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study. Oxid Med Cell Longev 2016;2572606.
Resumen
Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases.However, accuracy and reliability of these studiesmay be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performedwith573participants (aged67.3 ± 5.9) fromthe PREDIMED study (ISRCTN35739639).We used Folin-Ciocalteumethod to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration (𝛽 = −8.563; 𝑃 = 0.007), glucose concentration (𝛽 = −4.164; 𝑃 = 0.036), and diastolic blood pressure (𝛽 = −1.316; 𝑃 = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.

Ficheros en este registro:
Fichero: 
2572606.pdf
Descripción: 
Tamaño: 
1,28 MB
Formato: 
Adobe PDF


Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.