Dietary [alfa]-linolenic acid, marine [omega]-3 fatty acids, and mortality in a population with high fish consumption: findings from the PREvención con DIeta MEDiterránea (PREDIMED) study

Ros, E. (Emilio); Estruch, R. (Ramón); Martinez-Gonzalez, M.A. (Miguel Ángel); Salas-Salvado, J. (Jordi); Fito, M. (Montserrat); Corella, D. (Dolores); Martinez, J.A. (José Alfredo); Serra-Majem, L. (Luis); Muñoz, M.A. (Miguel Angel); Fiol, M. (Miquel); Aros, F. (Fernando); Sorli, J.V. (Jose V.); Lopez-Sabater, M.C. (M. Carmen); Serra-Mir, M. (Merce); Bullo, M. (Monica); Sanchez-Tainta, A. (Ana); Hu, F.B. (Frank B.); Guasch-Ferre, M. (Marta); Sala-Vila, A. (Aleix)

Keywords:

PREDIMED
Fish consumption
Materias Investigacion::Ciencias de la vida::Metabolismo
Dieta mediterránea
Materias Investigacion::Ciencias de la Salud::Medicina preventiva
Sudden cardiac death
Nutrition
Fatty acid

Issue Date:

2016

Publisher:

American Heart Association

Project:

the Spanish Ministry of Science and Innovation (MICINN) AGL2010-22319-C03-02 and AGL2009-13906-C02- 02
(Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045.
Instituto de Salud Carlos III (ISCIII)
Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/ 01292.
An unrestricted grant from the California Walnut Commission

ISSN:

2047-9980

Citation:

Sala-Vila A, Guasch-Ferre M, Hu FB, Sanchez-Tainta A, Bullo M, Serra-Mir M, et al. Dietary [alfa]-linolenic acid, marine [omega]-3 fatty acids, and mortality in a population with high fish consumption: findings from PREvención con DIeta MEDiterránea (PREDIMED) study. J Am Heart Assoc 2016;5(1):e002543

Abstract

Epidemiological evidence suggests a cardioprotective role of a-linolenic acid (ALA), a plant-derived x-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine x-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society’s recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day).

URI:

https://hdl.handle.net/10171/40060

DOI:

http://dx.doi.org/10.1161/JAHA.115.002543

Appears in Collections:

DA - Farmacia - CAFT - Artículos de revista
DA - Medicina - MPSP -Artículos de revista

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