Phase behavior of reverse poloxamers and poloxamines in water

Isasi-Allica, J.R. (José Ramón); Larrañeta, E. (Eneko)

Authors:

Isasi-Allica, J.R. (José Ramón)

Larrañeta, E. (Eneko)

Keywords:

Materias Investigacion::Química
Viscometry
Phase behavior
Poloxamine
Poloxamer

Issue Date:

2013

Publisher:

American Chemical Society

Project:

Ministerio de Ciencia e Innovación (project MAT2007-65752)

Publisher Version:

http://pubs.acs.org/doi/abs/10.1021/la304245p

ISSN:

0743-7463

Editorial note:

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Langmuir, copyright © American Chemical Society after peer review. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/la304245p

Citation:

Larrañeta E, Isasi JR. Phase behavior of reverse poloxamers and poloxamines in water. Langmuir 2013;29(4):1045–1053

Abstract

The phase behavior of two types of poly(ethylene oxide)/ poly(propylene oxide) (PEO/PPO) copolymers in aqueous solutions was studied by light scattering, viscometry and infrared spectroscopy. Both the reverse poloxamer (Pluronic 10R5) and the star type poloxamine (Tetronic 90R4) have practically the same PEO/PPO ratio with their hydrophobic blocks (PPO) located in the outer part. The temperature-composition phase diagrams show that both 10R5 and 90R4 tend to form aggregates in water. Up to four different phases can be detected in the case of Tetronic 90R4 for each temperature: unimers, random networks, micellar networks and macrophase separation. Viscometric and infrared measurements complemented the results obtained by light scattering and visual inspection.

URI:

https://hdl.handle.net/10171/40061

Appears in Collections:

DA - Ciencias - Química - Artículos de revista

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