Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Larrañeta, E. (Eneko) | - |
dc.creator | Isasi-Allica, J.R. (José Ramón) | - |
dc.date.accessioned | 2016-02-27T19:32:18Z | - |
dc.date.available | 2016-02-27T19:32:18Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Larrañeta E, Isasi JR. Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins. Carbohydr Polym 2014;102:674-681 | es_ES |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://hdl.handle.net/10171/40062 | - |
dc.description.abstract | Different types of gels were prepared by combining poloxamines (Tetronic), i.e. poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) octablock star copolymers, and cyclodextrins (CD). Two different poloxamines with the same molecular weight (ca. 7000) but different molecular architectures were used. For each of their four diblock arms, direct Tetronic 904 presents PEO outer blocks while in reverse Tetronic 90R4 the hydrophilic PEO blocks are the inner ones. These gels were prepared by combining α-CD and poloxamine aqueous solutions. The physicochemical properties of these systems depend on several factors such as the structure of the block copolymers and the Tetronic/α-CD ratio. These gels were characterized using differential scanning calorimetry (DSC), viscometry and X-ray diffraction measurements. The 90R4 gels present a consistency that makes them suitable for sustained drug delivery. The resulting gels were easily eroded: these complexes were dismantled when placed in a large amount of water, so controlled release of entrapped large molecules such as proteins (Bovine Serum Albumin, BSA) is feasible and can be tuned by varying the copolymer/CD ratio. | es_ES |
dc.description.sponsorship | Ministerio de Ciencia e Innovación (project 347 MAT2007-65752) and Universidad de Navarra (PIUNA). Gobierno de Navarra 348 grant (Plan de Formación y de I+D). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | Gobierno de Navarra 348 grant (Plan de Formación y de I+D). | - |
dc.relation | Ministerio de Ciencia e Innovación (project 347 MAT2007-65752) | - |
dc.relation | Universidad de Navarra (PIUNA). | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Non-Covalent Hydrogels | es_ES |
dc.subject | Cyclodextrins | es_ES |
dc.subject | Poloxamines | es_ES |
dc.subject | Proteins | es_ES |
dc.subject | Materias Investigacion::Química | es_ES |
dc.title | Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.editorial.note | This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/j.carbpol.2013.11.002 | es_ES |
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