Brain aging and Parkinson's disease: new therapeutic approaches using drugs delivery systems
Keywords: 
Materias Investigacion::Ciencias de la Salud::Neurología
Micro/nanoparticles
Drug delivery systems
GDNF
Alpha-synuclein
Therapeutic targets
Aging
Parkinson disease
Issue Date: 
2015
Publisher: 
Elsevier
ISSN: 
0378-5122
Citation: 
Rodríguez-Nogales C, Garbayo E, Carmona-Abellán MM, Luquin MR, Blanco-Prieto MJ. Brain aging and Parkinson's disease: new therapeutic approaches using drugs delivery systems. Maturitas 2016;84:25–31
Abstract
ABSTRACT The etiology and pathogenesis of Parkinson’s disease (PD) is unknown, aging being the strongest risk factor for brain degeneration. Understanding PD pathogenesis and how aging increases the risk of disease would aid the development of therapies able to slow or prevent the progression of this neurodegenerative disorder. In this review we provide an overview of the most promising therapeutic targets and strategies to delay the loss of dopaminergic neurons observed both in PD and aging. Among them, handling alphasynuclein toxicity, enhancing proteasome and lysosome clearance, ameliorating mitochondrial disruptions and modifying the glial environment are so far the most promising candidates. These new and conventional drugs may present problems related to their labile nature and to the difficulties in reaching the brain. Thus, we highlight the latest types of drug delivery system (DDS)-based strategies for PD treatment, including DDS for local and systemic drug delivery. Finally, the ongoing challenges for the discovery of new targets and the opportunities for DDS-based therapies to improve and efficacious PD therapy will be discussed.

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