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DC FieldValueLanguage
dc.creatorBlanco-Prieto, M.J. (María José)-
dc.creatorLuquin, M.R. (María Rosario)-
dc.creatorCarmona-Abellan, M. (M.)-
dc.creatorGarbayo, E. (Elisa)-
dc.creatorRodriguez-Nogales, C. (C.)-
dc.date.accessioned2016-03-01T13:42:55Z-
dc.date.available2016-03-01T13:42:55Z-
dc.date.issued2015-
dc.identifier.citationRodríguez-Nogales C, Garbayo E, Carmona-Abellán MM, Luquin MR, Blanco-Prieto MJ. Brain aging and Parkinson's disease: new therapeutic approaches using drugs delivery systems. Maturitas 2016;84:25–31es_ES
dc.identifier.issn0378-5122-
dc.identifier.urihttp://hdl.handle.net/10171/40096-
dc.description.abstractABSTRACT The etiology and pathogenesis of Parkinson’s disease (PD) is unknown, aging being the strongest risk factor for brain degeneration. Understanding PD pathogenesis and how aging increases the risk of disease would aid the development of therapies able to slow or prevent the progression of this neurodegenerative disorder. In this review we provide an overview of the most promising therapeutic targets and strategies to delay the loss of dopaminergic neurons observed both in PD and aging. Among them, handling alphasynuclein toxicity, enhancing proteasome and lysosome clearance, ameliorating mitochondrial disruptions and modifying the glial environment are so far the most promising candidates. These new and conventional drugs may present problems related to their labile nature and to the difficulties in reaching the brain. Thus, we highlight the latest types of drug delivery system (DDS)-based strategies for PD treatment, including DDS for local and systemic drug delivery. Finally, the ongoing challenges for the discovery of new targets and the opportunities for DDS-based therapies to improve and efficacious PD therapy will be discussed.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.subjectMaterias Investigacion::Ciencias de la Salud::Neurologíaes_ES
dc.subjectMicro/nanoparticleses_ES
dc.subjectDrug delivery systemses_ES
dc.subjectGDNFes_ES
dc.subjectAlpha-synucleines_ES
dc.subjectTherapeutic targetses_ES
dc.subjectAginges_ES
dc.subjectParkinson diseasees_ES
dc.titleBrain aging and Parkinson's disease: new therapeutic approaches using drugs delivery systemses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.maturitas.2015.11.009es_ES

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