Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model
Palabras clave : 
Oncolytic viruses
Pancreatic cancer
OSM
Andenovirus
NDV
Materias Investigacion::Ciencias de la Salud
Fecha de publicación: 
2015
Editorial : 
BioMed Central
ISSN: 
1476-4598
Cita: 
Nistal-Villan E, Buñuales M, Poutou J, González-Aparicio M, Bravo-Perez C, Quetglas JI,et al. Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model. Mol Cancer 2015;14(1):210
Resumen
The limited efficacy of current treatments against pancreatic cancer has prompted the search of new alternatives such as virotherapy. Activation of the immune response against cancer cells is emerging as one of the main mechanisms of action of oncolytic viruses (OV). Direct oncolysis releases tumor antigens, and viral replication within the tumor microenvironment is a potent danger signal. Arming OV with immunostimulatory transgenes further enhances their therapeutic effect. However, standard virotherapy protocols do not take full advantage of OV as cancer vaccines because repeated viral administrations may polarize immune responses against strong viral antigens, and the rapid onset of neutralizing antibodies limits the efficacy of redosing. An alternative paradigm based on sequential combination of antigenically distinct OV has been recently proposed.

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Enhanced therapeutic.pdf
Descripción: 
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1,95 MB
Formato: 
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