Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model
Keywords: 
Oncolytic viruses
Pancreatic cancer
OSM
Andenovirus
NDV
Materias Investigacion::Ciencias de la Salud
Issue Date: 
2015
Publisher: 
BioMed Central
ISSN: 
1476-4598
Citation: 
Nistal-Villan E, Buñuales M, Poutou J, González-Aparicio M, Bravo-Perez C, Quetglas JI,et al. Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model. Mol Cancer 2015;14(1):210
Abstract
The limited efficacy of current treatments against pancreatic cancer has prompted the search of new alternatives such as virotherapy. Activation of the immune response against cancer cells is emerging as one of the main mechanisms of action of oncolytic viruses (OV). Direct oncolysis releases tumor antigens, and viral replication within the tumor microenvironment is a potent danger signal. Arming OV with immunostimulatory transgenes further enhances their therapeutic effect. However, standard virotherapy protocols do not take full advantage of OV as cancer vaccines because repeated viral administrations may polarize immune responses against strong viral antigens, and the rapid onset of neutralizing antibodies limits the efficacy of redosing. An alternative paradigm based on sequential combination of antigenically distinct OV has been recently proposed.

Files in This Item:
Thumbnail
File
Enhanced therapeutic.pdf
Description
Size
1.95 MB
Format
Adobe PDF


Statistics and impact

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.