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dc.creatorCatalan, V. (Victoria)-
dc.creatorGomez-Ambrosi, J. (Javier)-
dc.creatorRodriguez, A. (Amaia)-
dc.creatorRamirez, B. (Beatriz)-
dc.creatorIzaguirre, M. (Maitane)-
dc.creatorHernandez-Lizoain, J.L. (Jose Luis)-
dc.creatorBaixauli-Fons, J. (Jorge)-
dc.creatorMarti-Cruchaga, P. (Pablo)-
dc.creatorValenti, V. (Víctor)-
dc.creatorMoncada, R. (Rafael)-
dc.creatorSilva, C. (Camilo)-
dc.creatorSalvador, J. (Javier)-
dc.creatorFrühbeck, G. (Gema)-
dc.date.accessioned2016-10-18T10:00:08Z-
dc.date.available2016-10-18T10:00:08Z-
dc.date.issued2016-
dc.identifier.citationCatalan V, Gomez-Ambrosi J, Rodriguez A, Ramirez B, Izaguirre M, Hernandez-Lizoain JL, et al. Increased Obesity-AssociatedCirculating Levels of the Extracellular Matrix Proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C Are Associated with Colon Cancer. PLoS ONE 2016;11(9):e0162189es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttps://hdl.handle.net/10171/41859-
dc.description.abstractExcess adipose tissue represents a major risk factor for the development of colon cancer with inflammation and extracellular matrix (ECM) remodeling being proposed as plausible mechanisms. The aim of this study was to investigate whether obesity can influence circulating levels of inflammation-related extracellular matrix proteins in patients with colon cancer (CC), promoting a microenvironment favorable for tumor growth. Methods Serum samples obtained from 79 subjects [26 lean (LN) and 53 obese (OB)] were used in the study. Enrolled subjects were further subclassified according to the established diagnostic protocol for CC (44 without CC and 35 with CC). Anthropometricmeasurements as well as circulating metabolites and hormoneswere determined. Circulating concentrations of the ECM proteins osteopontin (OPN), chitinase-3-like protein 1 (YKL-40), tenascin C (TNC) and lipocalin-2 (LCN-2) were determined by ELISA. Results Significant differences in circulating OPN, YKL-40 and TNC concentrations between the experimental groups were observed, being significantly increased due to obesity (P<0.01) and colon cancer (P<0.05). LCN-2 levels were affected by obesity (P<0.05), but no differences were detected regarding the presence or not of CC. A positive association (P<0.05) with different inflammatorymarkers was also detected.Conclusions To our knowledge, we herein show for the first time that obese patients with CC exhibit increased circulating levels of OPN, YKL-40 and TNC providing furtherevidence for the influence of obesity on CC development via ECM proteins, representing promising diagnostic biomarkers or target molecules for therapeutics.es_ES
dc.description.sponsorshipThis work was supported by Fondo de Investigación Sanitaria-FEDER, Instituto de Salud Carlos III (ISCIII) (PI12/00515, PI13/00460 and PI14/ 00950), by the Department of Health (48/2011 and 58/2011) of the Gobierno de Navarra of Spain, by Fundación Caja Navarra (20-2014) and by the ISCIII, Centro de InvestigaciónBiomédica en Red Fisiopatología de la Obesidad y Nutrición, CIBEROBN, Spain.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectObesityes_ES
dc.subjectColon Canceres_ES
dc.subjectExcess adipose tissuees_ES
dc.subjectMaterias Investigacion::Ciencias de la Salud::Endocrinologíaes_ES
dc.subjectMaterias Investigacion::Ciencias de la Salud::Nutrición y dietéticaes_ES
dc.titleIncreased obesity-associated circulating levels of the extracellular matrix proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C are associated with colon canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.editorial.noteThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es_ES
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0162189. eCollection 2016.es_ES

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