Effects of oral supplementation with alpha-lipoic acid and eicosapentaenoic acid in overweight/obese healthy women conjonintly with a hypocaloric diet
Palabras clave : 
Materias Investigacion::Ciencias de la Salud::Nutrición y dietética
Materias Investigacion::Farmacia::Farmacia y farmacología
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HUERTA, Ana Elsa. “Effects of oral supplementation with alpha-lipoic acid and eicosapentaenoic acid in overweight/obese healthy women conjonintly with a hypocaloric diet”. Moreno, M.J. y Martínez, J.A. (dir.). Tesis doctoral. Universidad de Navarra, Pamplona, 2016
Obesity is a multi-factorial chronic condition that increases the risk of some chronic diseases such as type 2 diabetes, hypertension and dyslipidemia, among others. There is strong scientific evidence that the pro-inflammatory state induced by enhanced adiposity levels plays an important role in the occurrence of obesity-related metabolic impairments. Actually, adipose tissue is an important endocrine organ with a key role in the inflammatory response during obesity through secretion of adipokines, and other mediators either proinflammatory or anti- inflammatory. In this context, it has been suggested that the supplementation with anti- inflammatory or anti-oxidant compounds could contribute not only to counteract the obesity- related clinical complications but also to induce weight loss. The general aim of the current work was to analyze the efficacy of a dietary supplementation with eicosapentaenoic acid (EPA) and/or α-lipoic acid in combination with a moderately energy-restricted diet on body weight loss and on some metabolic and inflammatory status biomarkers in metabolically healthy overweight/obese women, as well as to characterize the transcriptomic and epigenetic mechanisms that could be involved. In order to achieve these goals, Caucasian healthy overweight/obese women (n= 77) aged 20- 50 years followed a 10-weeks nutritional intervention with a hypocaloric diet (-30% from the total energy expenditure) after being randomly assigned to one of the four parallel experimental groups: 1) Control group (placebo); 2) EPA group (1.3 g/day of EPA); 3) α-lipoic acid group (0.3 g/day of α-lipoic acid) and 4) EPA + α-lipoic acid (1.3 g/day of EPA + 0.3 g/day of α-lipoic acid). At the end of the study, blood samples from 73 volunteers were available and subcutaneous abdominal adipose tissue (SAAT) biopsies from 57 women were obtained. Moreover, within an in vitro approach, human cultured adipocytes were treated with EPA (100-200 µM) or α-lipoic acid (100-250 µM) during 24 h.

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