Nefrotoxicidad nephrotoxicity Materias Investigacion::Ciencias de la Salud::Química médica Ochratoxin A (OTA) metabolism metabolismo
Fecha de publicación:
Fecha de la defensa:
PASTOR, Laura. “Sex differences in ochratoxin A nephrotoxicity: A molecular approach to the mechanism of action”. López de Cerain Salsamendi, A. y Vettorazzi Armental, A. (dir.). Tesis doctoral. Universidad de Navarra, Pamplona, 2017.
This work is included in the line of research carried out in Toxicology which studies the mycotoxin ochratoxin A (OTA) from the point of view of its mechanism of action. OTA causes various toxic effects, such as nephrotoxicity, hepatotoxicity, immunosuppression, neurotoxicity and teratogenicity. However, the main issue concerning OTA effect is its carcinogenic potential in kidney, the target organ. The aim of this research project was to explore the impact of sex on OTA-induced gene expression response in order to determine the key events that might be involved in the early events of the carcinogenic process.