Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer
Palabras clave : 
Materias Investigacion::Farmacia::Farmacia y farmacología
Pharmacometrics
Fecha incorporación: 
14-nov-2017
Fecha de la defensa: 
29-sep-2017
Cita: 
GARGÍA-CREMADES, María. “Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer”. Fernández de Trocóniz, J.I. (dir.). Tesis doctoral. Universidad de Navarra, Pamplona, 2017.
Resumen
This thesis performs a retrospective evaluation of data generated for the cytotoxic/cytostatic antimetabolite drug gemcitabine along the different phases of drug development. Using these data, and through data analysis and simulations-based translational exercise, a model-based framework in oncology, relating in vitro and in vivo pre-clinical pharmacokinetic (PK) and tumour size (TS) information, with response outcome obtained in clinical trials, has been developed.

Ficheros en este registro:
Fichero: 
Tesis_Garcia-Cremades.pdf
Descripción: 
Tamaño: 
9,99 MB
Formato: 
Adobe PDF


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