Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Huarte-Martínez, M. (Maite) | - |
dc.creator | Athie-Cuervo, A. (Alejandro) | - |
dc.date.accessioned | 2017-12-07T07:59:56Z | - |
dc.date.available | 2017-12-07T07:59:56Z | - |
dc.date.issued | 2017-12-05 | - |
dc.date.submitted | 2017-09-28 | - |
dc.identifier.citation | ATHIE CUERVO, Alejandro. “Somatic Copy-Number Alterations across Human Cancers from LncRNA Perspective”. Huarte, M. (dir.). Tesis doctoral. Universidad de Navarra, Pamplona, 2017. | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/45008 | - |
dc.description.abstract | The genome of a tumor cell presents thousands of genomic alterations including base-substitutions and somatic copy number alterations (SCNAs). SCNAs comprise amplifications and deletions of big chromosomal regions usually containing hundreds of genes. Some of these regions harbor well-studied cancer drivers; however many others do not contain a known driver. The analysis of SCNA focusing on the non-coding genome helped us pinpoint a list of copy number altered long noncoding RNAs (lncRNAs). In order to validate our findings we experimentally characterized functionally and mechanistically a lncRNA amplified in lung cancer which we named LUAD-amp-1. LUAD-amp-1 acts as an oncogenic lncRNA, and its expression is induced by the transcription factor NF-B upon TNF treatment. Moreover, LUAD-amp-1 is implicated in the inhibition of a set of NF-B regulated genes including TNF itself. LUAD-amp-1 molecular mechanism relies on its association with SART3, altering its localization and modulating the nuclear translocation of its associated protein USP4. | en |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | * |
dc.subject | Materias Investigacion::Ciencias de la Salud::Oncología | es_ES |
dc.title | Somatic Copy-Number Alterations across Human Cancers from LncRNA Perspective | es_ES |
dc.type | info:eu-repo/semantics/doctoralThesis | es_ES |
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