Obesidad Obesity Genética Genetics Materias Investigacion::Ciencias de la Salud::Genética
Fecha de la defensa:
GOÑI MATEOS, Leticia. “Nutrigenetic approaches for personalized management of obesity and metabolic syndrome traits”. Martínez Hernández, J.A. y Cuervo Zapatel, M. (dirs.). Tesis doctoral. Universidad de Navarra, Pamplona, 2017.
Based on the available evidence, on the one hand we proposed that different genetic variants or a genetic risk score influence obesity and its related comorbidities susceptibility or the response to a weight loss diet. On the other hand, focusing on gene-environment interactions we hypothesized that dietary factors may modify the association between the genotype and the studied phenotype.
The general aim of this work was to study the association between different genetic variants and a genetic risk score with obesity related features such as adiposity, blood pressure, and lipid and glucose metabolism traits, as well as the effect of dietary factors on such relationship.
The specific objectives of the present research were: 1. To search for potential polymorphisms associated with obesity and body weight regulation and to identify other metabolic biomarkers such as epigenetics and gut microbiota related to the obesity phenotype. 2. To evaluate the validaty of a food groups frequency questionnaire based on an exchange system for assess dietary habits in a short manner. 3. To test the association between a multi-trait genetic risk score and body fatness and to identify phenotype and genotype variables related to BMI status. 4. To examine the effect of genetic variants on changes in body fatness and body composition measurements in response to different weigh-loss diets varying in macronutrient distribution. 5. To evaluate the potential association between different polymorphisms and obesity related traits (blood pressure, glucose metabolism and lipid metabolism), and to investigate the possible influence of the diet on that association.