Full metadata record
DC Field | Value | Language |
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dc.creator | Arpon, A. (Ana) | - |
dc.creator | Milagro-Yoldi, F.I. (Fermín Ignacio) | - |
dc.creator | Laja, A. (Ana) | - |
dc.creator | Segura, V. (Víctor) | - |
dc.creator | Saenz-de-Pipaon, M. (Miguel) | - |
dc.creator | Riezu-Boj, J.I. (José Ignacio) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.date.accessioned | 2018-01-04T10:56:02Z | - |
dc.date.available | 2018-01-04T10:56:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Arpón A, Milagro F.I., Laja A., Segura V., Sáenz de Pipaón M., Riezu-Boj J.I., Martínez J.A. Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment. Epigenomics 2018, 10(1): 91-103. doi: 10.2217/epi-2017-0082 | es_ES |
dc.identifier.issn | 1750-1911 | - |
dc.identifier.issn | 1750-192X | - |
dc.identifier.uri | https://hdl.handle.net/10171/45459 | - |
dc.description.abstract | AIM: To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells. PATIENTS & METHODS: Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (Spain) were assessed at 12 months of gestational age, whereas Bayley Scale of Infant Development was evaluated at 24/36 months. RESULTS: From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors. CONCLUSION: SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmental diseases in newborns. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Future Medicine | es_ES |
dc.rights | info:eu-repo/semantics/embargoedAccess | es_ES |
dc.subject | Bayley scale | es_ES |
dc.subject | SLC6A3 | es_ES |
dc.subject | Epigenetics | es_ES |
dc.subject | Full-term newborns | es_ES |
dc.subject | Peripheral white blood cells | es_ES |
dc.subject | Prematurity | es_ES |
dc.subject | Preterm newborns | es_ES |
dc.title | Methylation changes and pathways affected in preterm birth: a role for SLC6A3 in neurodevelopment | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://www.futuremedicine.com/doi/10.2217/epi-2017-0082 | es_ES |
dc.identifier.doi | 10.2217/epi-2017-0082 | - |
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