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dc.creatorAcanda-de-la-Rocha, A.M. (Arlet María)-
dc.creatorLopez-Bertoni, H. (Hernando)-
dc.creatorGuruceaga, E. (Elizabeth)-
dc.creatorGonzalez-Huarriz, M. (Marisol)-
dc.creatorMartinez-Velez, N. (Naiara)-
dc.creatorXipell, E. (Enric)-
dc.creatorFueyo, J. (Juan)-
dc.creatorGomez-Manzano, C. (Candelaria)-
dc.creatorAlonso, M.M. (Marta M.)-
dc.identifier.citationAcanda-de-la-Rocha, A.M. (Arlet María); Lopez-Bertoni, H. (Hernando); Guruceaga, E. (Elizabeth); et al. "Analysis of SOX2-regulated transcriptome in glioma stem cells". PlosOne. 11 (9), 2016,1-20es_ES
dc.description.abstractIntroduction Glioblastoma is the most malignant brain tumor in adults and is associated with poor sur- vival despite multimodal treatments. Glioma stem-like cells (GSCs) are cells functionally defined by their self-renewal potential and the ability to reconstitute the original tumor upon orthotopic implantation. They have been postulated to be the culprit of glioma chemo- and radio-resistance ultimately leading to relapse. Understanding the molecular circuits govern- ing the GSC compartment is essential. SOX2, a critical transcription regulator of embryonic and neural stem cell function, is deregulated in GSCs however; the precise molecular path- ways regulated by this gene in GSCs remain poorly understood. Results We performed a genome-wide analysis of SOX2-regulated transcripts in GSCs, using a microarray. We identified a total of 2048 differentially expressed coding transcripts and 261 non-coding transcripts. Cell adhesion and cell-cell signaling are among the most enriched terms using Gene Ontology (GO) classification. The pathways altered after SOX2 down- modulation includes multiple cellular processes such as amino-acid metabolism and inter- cellular signaling cascades. We also defined and classified the set of non-coding transcripts differentially expressed regulated by SOX2 in GSCs, and validated two of them. Conclusions We present a comprehensive analysis of the transcriptome controlled by SOX2 in GSCs, gaining insights in the understanding of the potential roles of SOX2 in glioblastoma.es_ES
dc.description.sponsorshipEuropean Union, Instituto de Salud Carlos III, los Fondos Feder Europeos, Spanish Ministry of Economy and competitiveness, L‘OREAL-Unesco Foundation, Department of Health of the Government of Navarra, The Basque Foundation for Health Research, Fundación Caja Navarra, the Friends of the University of Navarra Foundation.es_ES
dc.titleAnalysis of SOX2-regulated transcriptome in glioma stem cellses_ES

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