Identification and analysis of long non-coding RNAs related to viral infection and antiviral response
Palabras clave : 
viral infection
antiviral response
Materias Investigacion::Ciencias de la Salud::Genética
Fecha de publicación: 
Fecha de la defensa: 
BARRIOCANAL, Marina. "Identification and analysis of long non-coding RNAs related to viral infection and antiviral response". Fortes, P. (dir.). Tesis doctoral. Universidad de Navarra, Pamplona, 2017.
One of the principles of molecular biology is that the information collected in the DNA is transcribed to RNA and then translated to proteins that will exert their function in the cell. This DNA comprises only around 2-4% of the human genome. In the last decades, the study of the non-coding transcriptome has led to the discovery of multiple functional non-coding RNAs, including long noncoding RNAs (lncRNAs). LncRNAs are deregulated in most cell processes; and some lncRNAs have been identified that act as key regulators of cell proliferation, development or cell homeostasis. However, the function of most lncRNAs is still unknown. Further, lncRNAs are highly modified by evolution, suggesting that they may play a relevant role in those processes with a strong evolutionary pressure. As one of the drivers of evolution is the cellular antiviral response, we hypothesized that lncRNAs could play a fundamental role in this response. The aim of this work was to identify and analyse lncRNAs involved in the antiviral cellular response.

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