Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Paiva, B. (Bruno) | - |
dc.creator | Corchete, L.A. (Luis A.) | - |
dc.creator | Vidriales, M.B. (María Belén) | - |
dc.creator | Puig, N. (Noemí) | - |
dc.creator | Maiso, P. (Patricia) | - |
dc.creator | Rodriguez, I. (Idoia) | - |
dc.creator | Alignani, D. (Diego) | - |
dc.creator | Burgos, L. (Leire) | - |
dc.creator | Sanchez, M.L. (Maria Luz) | - |
dc.creator | Barcena, P. (Paloma) | - |
dc.creator | Echeveste, M.A. (Maria Asuncion) | - |
dc.creator | Hernandez, M.T. (Miguel Teodoro) | - |
dc.creator | García-Sanz, R. (Ramón) | - |
dc.creator | Ocio, E.M. (Enrique M.) | - |
dc.creator | Oriol, A. (Albert) | - |
dc.creator | Gironella, M. (Mercedes) | - |
dc.creator | Palomera, L. (Luis) | - |
dc.creator | Arriba, F. (Felipe) de | - |
dc.creator | Gonzalez, Y. (Yolanda) | - |
dc.creator | Johnson, S.K. (Sarah K.) | - |
dc.creator | Epstein, J. (Joshua) | - |
dc.creator | Barlogie, B. (Bart) | - |
dc.creator | Lahuerta, J.J. (Juan José) | - |
dc.creator | Bladé, J. (Joan) | - |
dc.creator | Orfao, A. (Alberto) | - |
dc.creator | Mateos, M.V. (María Victoria) | - |
dc.creator | San-Miguel, J.F. (Jesús F.) | - |
dc.date.accessioned | 2018-05-09T08:41:31Z | - |
dc.date.available | 2018-05-09T08:41:31Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Paiva, B. (Bruno); Corchete, L.A. (Luis A.); Vidriales, M.B. (María Belén); et al. "Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance". Blood. 127, 2016, 1896 - 1906 | es |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | https://hdl.handle.net/10171/52182 | - |
dc.description.abstract | Persistence of chemoresistant minimal residual disease (MRD) plasma cells (PCs) is associated with inferior survival in multiple myeloma (MM). Thus, characterization of the minor MRD subclone may represent a unique model to understand chemoresistance, but to our knowledge, the phenotypic and genetic features of the MRD subclone have never been investigated. Here, we compared the antigenic profile of MRD vs diagnostic clonal PCs in 40 elderly MM patients enrolled in the GEM2010MAS65 study and showed that the MRD subclone is enriched in cells overexpressing integrins (CD11a/CD11c/CD29/CD49d/CD49e), chemokine receptors (CXCR4), and adhesion molecules (CD44/CD54). Genetic profiling of MRD vs diagnostic PCs was performed in 12 patients; 3 of them showed identical copy number alterations (CNAs), in another 3 cases, MRD clonal PCs displayed all genetic alterations detected at diagnosis plus additional CNAs that emerged at the MRD stage, whereas in the remaining 6 patients, there were CNAs present at diagnosis that were undetectable in MRD clonal PCs, but also a selected number of genetic alterations that became apparent only at the MRD stage. The MRD subclone showed significant downregulation of genes related to protein processing in endoplasmic reticulum, as well as novel deregulated genes such as ALCAM that is prognostically relevant in MM and may identify chemoresistant PCs in vitro. Altogether, our results suggest that therapy-induced clonal selection could be already present at the MRD stage, where chemoresistant PCs show a singular phenotypic signature that may result from the persistence of clones with different genetic and gene expression profiles. This trial was registered at www.clinicaltrials.gov as #NCT01237249. | es_ES |
dc.description.sponsorship | This study was supported by the Cooperative Research Thematic Network grants RD12/0036/0048, RD12/0036/0058, RD12/0036/0046, RD12/0036/0069 of the Red de Cancer (Cancer Network of Excellence); Instituto de Salud Carlos III, Spain, Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria (FIS: PI060339; 06/1354; 02/0905; 01/0089/01-02; PS09/01897/01370; G03/136; Sara Borrell: CD13/00340); and Asociación Española Contra el Cáncer (GCB120981SAN), Spain. The study was also supported internationally by the International Myeloma Foundation (IMF) Junior Grant, the Black Swan Research Initiative of the IMF, the Multiple Myeloma Research Foundation (MMRF) research fellow award, the Qatar National Research Fund (QNRF) Award No. 7-916-3-237, the AACR-Millennium Fellowship in Multiple Myeloma Research (15-40-38-PAIV), and the European Research Council (ERC) 2015 Starting Grant. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society of Hematology | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/680200/EU | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Hematología | es_ES |
dc.title | Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.bloodjournal.org/content/early/2016/04/26/blood-2016-03-705319 | es_ES |
dc.identifier.doi | 10.1182/blood-2015-08-665679 | - |
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