Full metadata record
DC Field | Value | Language |
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dc.creator | Collantes, M. (María) | - |
dc.creator | Martinez-Velez, N. (Naiara) | - |
dc.creator | Zalacain, M. (Marta) | - |
dc.creator | Marrodán, L. (Lucía) | - |
dc.creator | Ecay, M. (Margarita) | - |
dc.creator | Garcia-Velloso, M. J. (María José) | - |
dc.creator | Alonso-Roldán, M.M. (Marta María) | - |
dc.creator | Patiño-García, A. (Ana) | - |
dc.creator | Peñuelas-Sanchez, I. (Ivan) | - |
dc.date.accessioned | 2018-12-12T10:17:41Z | - |
dc.date.available | 2018-12-12T10:17:41Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Collantes-Martínez, M. (María); Martínez-Vélez, N. (Naiara); Zalacain-Díez, M. (Marta); et al. "Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [18F]FDG and sodium [18F]fluoride PET". BMC cancer. 18 (1), 2018, 1193 | es |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://hdl.handle.net/10171/56011 | - |
dc.description.abstract | BACKGROUND: Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([18F] FDG) and sodium [18F] Fluoride (Na [18F] F) PET scans in orthotopic murine models of osteosarcoma to describe the metabolic pattern of the tumors, to detect and diagnose tumors and to evaluate the efficacy of a new treatment based in oncolytic adenoviruses. METHODS: Orthotopic osteosarcoma murine models were created by the injection of 143B and 531MII cell lines. [18F]FDG and Na [18F] F PET scans were performed 30 days (143B) and 90 days (531MII) post-injection. The antitumor effect of two doses (107 and 108 pfu) of the oncolytic adenovirus VCN-01 was evaluated in 531 MII model by [18F] FDG PET studies. [18F] FDG uptake was quantified by SUVmax and Total Lesion Glycolysis (TLG) indexes. For Na [18F] F, the ratio tumor SUVmax/hip SUVmax was calculated. PET findings were confirmed by histopathological techniques. RESULTS: The metabolic pattern of tumors was different between both orthotopic models. All tumors showed [18F] FDG uptake, with a sensitivity and specificity of 100%. The [18F] FDG uptake was significantly higher for the 143B model (p < 0.001). Sensitivity for Na [18F] F was around 70% in both models, with a specificity of 100%. 531MII tumors showed a heterogeneous Na [18F] F uptake, significantly higher than 143B tumors (p < 0.01). | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Animal models | - |
dc.subject | Osteosarcoma | - |
dc.subject | Pet | - |
dc.title | Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [18F]FDG and sodium [18F]fluoride PET | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | This is an open access article distributed under the Creative Commons: Atribution License (cc BY) | - |
dc.identifier.doi | 10.1186/s12885-018-5122-y | - |
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