Materias Investigacion::Ciencias de la Salud::Oncología
Fecha de publicación:
Fecha de la defensa:
ORDÓÑEZ CIRIZA, Raquel. "New Epigenetic Targets in Multiple Myeloma". Prósper, F. y Agirre , X. (dir.). Tesis doctoral. Universidad de Navarra, 2018.
Over recent years, intense efforts have been focused on unraveling the molecular mechanisms underlying
Multiple Myeloma (MM) onset and progression. However, previous reports describing an abnormal genomic and epigenetic landscape of MM patients have not been fully capable of explaining the pathogenesis of the disease. An integrative multilayered epigenomic characterization of MM patients could provide a global view of the genome function and regulation, shedding light into the core mechanisms underlying myelomagenesis, and leading to the identification of specific targets and epigenetic drivers for this disease.
In order to elucidate this hypothesis, we have established the following principal objectives:
1. To characterize in detail the reference epigenome of MM patients in the context of B cell differentiation.
2. To detect, characterize and annotate epigenetic regulatory elements that could represent MM-specific epigenetic drivers.
3. To identify potential therapeutic targets and rational therapeutic approaches based on the chromatin landscape of MM cells.