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dc.creatorGonzález, J. (Jessica)-
dc.creatorRodriguez-Fraile, M. (Macarena)-
dc.creatorRivera, P. (Pilar)-
dc.creatorRestituto, P. (Patricia)-
dc.creatorColina, I. (Inmaculada)-
dc.creatorCalleja, M. (María)-
dc.creatorAlcaide, A.B. (Ana Belén)-
dc.creatorCampo, A. (Arantza)-
dc.creatorBertó, J. (Juan)-
dc.creatorSeijo, L. (Luis)-
dc.creatorPérez, T. (Teresa)-
dc.creatorZulueta, J.J. (Javier J.)-
dc.creatorVaro, N. (Nerea)-
dc.creatorDe-Torres, J.P. (Juan Pablo)-
dc.date.accessioned2019-05-31T07:24:09Z-
dc.date.available2019-05-31T07:24:09Z-
dc.date.issued2019-
dc.identifier.citationGonzález, J. (Jessica); Rodriguez-Fraile, M. (Macarena); Rivera, P. (Pilar); et al. "Trabecular bone score in active or former smokers with and without COPD". Plos one. 14 (2), 2019, 1 - 13es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10171/57256-
dc.description.abstractAbstract Background Smoking is a recognized risk factor for osteoporosis. Trabecular bone score (TBS) is a novel texture parameter to evaluate bone microarchitecture. TBS and their main determinants are unknown in active and former smokers. Objective To assess TBS in a population of active or former smokers with and without Chronic Obstructive Pulmonary Disease (COPD) and to determine its predictive factors. Methods Active and former smokers from a pulmonary clinic were invited to participate. Clinical features were recorded and bone turnover markers (BTMs) measured. Lung function, low dose chest Computed Tomography scans (LDCT), dual energy absorptiometry (DXA) scans were performed and TBS measured. Logistic regression analysis explored the relationship between measured parameters and TBS. Results One hundred and forty five patients were included in the analysis, 97 (67.8%) with COPD. TBS was lower in COPD patients (median 1.323; IQR: 0.13 vs 1.48; IQR: 0.16, p = 0.003). Regression analysis showed that a higher body mass index (BMI), younger age, less number of exacerbations and a higher forced expiratory volume-one second (FEV1%) was associated with better TBS (β = 0.005, 95% CI:0.000–0.011, p = 0.032; β = -0.003, 95% CI:-0.007(-)-0.000, p = 0.008; β = -0.019, 95% CI:-0.034(-)-0.004, p = 0.015; β = 0.001, 95% CI:0.000–0.002, p = 0.012 respectively). The same factors with similar results were found in COPD patients. Conclusions A significant proportion of active and former smokers with and without COPD have an affected TBS. BMI, age, number of exacerbations and the degree of airway obstruction predicts TBS values in smokers with and without COPD. This important information should be considered when evaluating smokers at risk of osteoporosis.es_ES
dc.description.sponsorshipFunding was provided by Roche to Dr Nerea Varo. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.language.isospaes_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.titleTrabecular bone score in active or former smokers with and without COPDes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversion10.1371/journal.pone.0209777es_ES
dc.description.noteThis is an open access article distributed under the Creative Commons: Atribution License (cc BY)es_ES
dc.identifier.doi10.1371/journal.pone.0209777-
dadun.citation.endingPage13es_ES
dadun.citation.number2es_ES
dadun.citation.publicationNamePlos onees_ES
dadun.citation.startingPage1es_ES
dadun.citation.volume14es_ES

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