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dc.creatorLorente, L. (Leonardo)-
dc.creatorMartín, M.M. (María del Mar)-
dc.creatorRamos, L. (Luis)-
dc.creatorCaceres, J.J. (Juan J.)-
dc.creatorSole-Violan, J. (Jordi)-
dc.creatorArgueso, M. (Mónica)-
dc.creatorJimenez, A. (Alejandro)-
dc.creatorBorreguero-Leon, J.M. (Juan María)-
dc.creatorOrbe, J. (Josune)-
dc.creatorRodriguez, J.A. (José Antonio)-
dc.creatorParamo, J.A. (José Antonio)-
dc.date.accessioned2019-06-11T10:18:08Z-
dc.date.available2019-06-11T10:18:08Z-
dc.date.issued2015-
dc.identifier.citationLorente, L. (Leonardo); Martín, M.M. (María del Mar); Ramos, L. (Luis); et al. "Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction". BMC Neurology. 14 (111), 2015, 1 - 6es_ES
dc.identifier.issn1471-2377-
dc.identifier.urihttp://hdl.handle.net/10171/57775-
dc.description.abstractBackground: In the last years, circulating matrix metalloproteinases (MMP)-9 levels have been associated with functional outcome in ischemic stroke patients. However the prognostic value of circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and MMP-10 in functional outcome of ischemic stroke patients has been scarcely studied. In addition, to our knowledge, serum MMP-9, MMP-10 and TIMP-1 levels in patients with malignant middle cerebral artery infarction (MMCAI) for mortality prediction have not been studied, and these were the objectives of this study. Methods: This was a multicenter, observational and prospective study carried out in six Spanish Intensive Care Units. We included patients with severe MMCAI defined as Glasgow Coma Scale (GCS) lower than 9. We measured circulating levels of MMP-9, MMP-10, TIMP-1, in 50 patients with severe MMCAI at diagnosis and in 50 healthy subjects. Endpoint was 30-day mortality. Results: Patients with severe MMCAI showed higher serum levels of MMP-9 (p = 0.001), MMP-10 (p < 0.001), and TIMP-1 (p = 0.02) than healthy subjects. Non-surviving MMCAI patients (n = 26) compared to survivor ones (n = 24) showed higher circulating levels of TIMP-1 (p < 0.001), MMP-10 (p = 0.02) and PAI-1(p = 0.02), and lower MMP-9 levels (p = 0.04). Multiple binomial logistic regression analysis showed that serum TIMP-1 levels > 239 ng/mL are associated with 30-day mortality (OR = 5.82; 95 % CI = 1.37-24.73; P = 0.02) controlling for GCS and age. The area under the curve for TIMP-1 as predictor of 30-day mortality was 0.81 (95 % CI = 0.67-0.91; P < 0.001). We found an association between circulating levels of TIMP-1 and MMP-10 (rho = 0.45; P = 0.001), plasminogen activator inhibitor (PAI)-1 (rho = 0.53; P < 0.001), and tumor necrosis factor (TNF)-alpha (rho = 0.70; P < 0.001). Conclusions: The most relevant and new findings of our study, were that serum TIMP-1 levels in MMCAI patients were associated with mortality, and could be used as a prognostic biomarker of mortality in MMCAI patients.es_ES
dc.description.sponsorshipThis study was supported by fundings from Fundación Canaria de Investigación Sanitaria (FUNCANIS) (La Laguna, Tenerife, Spain) and F.I.M.A. (Pamplona, Navarra, Spain).es_ES
dc.language.isoenges_ES
dc.publisherBMCes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectTIMP-1es_ES
dc.subjectIschemic strokees_ES
dc.subjectPatientses_ES
dc.subjectMortalityes_ES
dc.subjectInjuryes_ES
dc.titleSerum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarctiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversion10.1186/s12883-015-0364-7es_ES
dc.description.noteThis is an open access article distributed under the Creative Commons: Atribution License (cc BY)es_ES
dc.identifier.doi10.1186/s12883-015-0364-7-
dadun.citation.endingPage6es_ES
dadun.citation.number111es_ES
dadun.citation.publicationNameBMC Neurologyes_ES
dadun.citation.startingPage1es_ES
dadun.citation.volume14es_ES

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