Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Fernandez-Montero, A. (Alejandro) | - |
dc.creator | Argemí-Ballbé, J.M. (José María) | - |
dc.creator | Rodríguez-García, J.A. (José Antonio) | - |
dc.creator | Ariño-Plana, A.H. (Arturo Hugo) | - |
dc.creator | Moreno, L. (Laura) | - |
dc.date.accessioned | 2021-08-10T07:57:28Z | - |
dc.date.available | 2021-08-10T07:57:28Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Fernández-Montero, A. (Alejandro Romualdo); Argemí-Ballbé, J. (José María); Rodríguez-García, J. (José Antonio); et al. "Validation of a rapid antigen test as a screening tool for SARS-CoV-2 infection in asymptomatic populations. Sensitivity, specificity and predictive values". Clinical Medicine. 37, 2021, 100954 | es |
dc.identifier.issn | 1470-2118 | - |
dc.identifier.uri | https://hdl.handle.net/10171/61233 | - |
dc.description.abstract | Background: Early diagnosis of SARS-CoV-2 infection is essential to reduce disease spread. Rapid antigen tests have not been sufficiently evaluated in asymptomatic patients to be used as massive population screening tools. Methods: Head-to-head evaluation of Roche SARS-CoV-2 Rapid Antigen Test and real-time reverse transcription polymerase chain reaction (RT-PCR) as SARS-CoV-2 screening tools performed in asymptomatic adults from a semi-closed community in University of Navarra (Spain) from November 2020 to January 2021. Sensitivity, specificity and predictive values were calculated using RT-PCR as reference method. Findings: Roche SARS-CoV-2 Rapid Antigen Test was performed on 2542 asymptomatic adults in a community with a SARS-CoV-2 incidence of 1·93%. It showed a sensitivity of 71·43% (CI 95%: 56·74 - 83·42) and a specificity of 99·68% (CI 95%: 99·37 - 99·86). Positive Predictive Value was 81·4 (CI 95% 66·6 - 91·61) and Negative Predictive Value was 99·44 (CI 95% 99·06 - 99·69). Test sensitivity was related to viral load, with higher sensitivity in RT-PCR cycle threshold (Ct) values under 25 (93·75%, CI 95%: 71·96 - 98·93), that dropped to 29·41% (CI 95%: 10·31- 55·96) in RT-PCR Ct values above 25. Interpretation: This study suggests that rapid antigen tests are less effective in asymptomatic population, when compared with RT-PCR. | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | COVID-19 | - |
dc.subject | RT-PCR | - |
dc.subject | Rapid antigen detection | - |
dc.subject | SARS-CoV-2 | - |
dc.subject | Screening tool | - |
dc.title | Validation of a rapid antigen test as a screening tool for SARS-CoV-2 infection in asymptomatic populations. Sensitivity, specificity and predictive values | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.identifier.doi | 10.1016/j.eclinm.2021.100954 | - |
dadun.citation.publicationName | Clinical Medicine | - |
dadun.citation.startingPage | 100954 | - |
dadun.citation.volume | 37 | - |
Ficheros en este ítem:
Estadísticas e impacto
Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.