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Campo DC | Valor | Lengua/Idioma |
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dc.creator | Bella-Carreño, Á. (Ángela) | - |
dc.creator | Di-Trani, C.A. (Claudia Augusta) | - |
dc.creator | Fernández-Sendín, M. (Myriam) | - |
dc.creator | Arrizabalaga, L. (Leire) | - |
dc.creator | Cirella, A. (Assunta) | - |
dc.creator | Teijeira, A. (Álvaro) | - |
dc.creator | Medina-Echeverz, J. (José) | - |
dc.creator | Melero, I. (Ignacio) | - |
dc.creator | Berraondo, P. (Pedro) | - |
dc.creator | Aranda, F. (Fernando) | - |
dc.date.accessioned | 2021-09-14T12:49:58Z | - |
dc.date.available | 2021-09-14T12:49:58Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Bella-Carreño, Á. (Ángela); Di-Trani, C. A.; Fernandez-Sendin, M.; et al. "Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications". Cancers. 13 (5), 2021, 963 | es |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://hdl.handle.net/10171/61996 | - |
dc.description.abstract | Simple Summary Peritoneal carcinomatosis mouse models as a platform to test, improve and/or predict the appropriate therapeutic interventions in patients are crucial to providing medical advances. Here, we overview reported mouse models to explore peritoneal carcinomatosis in translational biomedical research. Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents. | - |
dc.description.sponsorship | This work was supported by Instituto de Salud Carlos III (PI20/00002, PI19/01128,) cofinanced by Fondos FEDER “A way to make Europe” and Joint Translational Call for Proposals 2015 (JTC 2015), TRANSCAN456 2 (code: TRS-2016-00000371), Gobierno de Navarra Proyecto LINTERNA Ref.: 0011-1411-2020-000075. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 765394. F.A. receives a Miguel Servet I (CP19/00114) contract from ISCIII (Instituto de Salud Carlos III) co-financed by FSE (Fondo Social Europeo) "Investing in your future". Á.B. is recipients of PFIS fellowship from ISCIII (FI20/00058), and M.F.-S. is recipients for a fellowship of the Aid Program Assigned to Projects from the University of Navarra. Á.T. has received funding from La Caixa research foundation LCF/BQ/LR18/11640014. | - |
dc.language.iso | en | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/765394/EU | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Peritoneal carcinomatosis | - |
dc.subject | Animal model | - |
dc.subject | Translational research | - |
dc.subject | Peritoneal microenvironment | - |
dc.subject | Metastasis | - |
dc.title | Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications | - |
dc.type | info:eu-repo/semantics/review | - |
dc.description.note | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | - |
dc.identifier.doi | 10.3390/cancers13050963 | - |
dadun.citation.startingPage | 963 | - |
dadun.citation.volume | 13 | - |
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