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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Izaguirre, M. (Maitane) | - |
dc.creator | Gomez-Ambrosi, J. (Javier) | - |
dc.creator | Rodriguez, A. (Amaia) | - |
dc.creator | Ramirez, B. (Beatriz) | - |
dc.creator | Becerril, S. (Sara) | - |
dc.creator | Valenti, V. (Víctor) | - |
dc.creator | Moncada, R. (Rafael) | - |
dc.creator | Unamuno, X. (Xabier) | - |
dc.creator | Silva, C. (Camilo) | - |
dc.creator | Higuera, M. (Magdalena) de la | - |
dc.creator | Salvador, J. (Javier) | - |
dc.creator | Monreal, J.I. (José Ignacio) | - |
dc.creator | Frühbeck, G. (Gema) | - |
dc.creator | Catalan, V. (Victoria) | - |
dc.date.accessioned | 2021-10-21T08:00:44Z | - |
dc.date.available | 2021-10-21T08:00:44Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Izaguirre, M. (Maitane); Gomez-Ambrosi, J. (Javier); Rodriguez, A. (Amaia); et al. "GLP-1 limits adipocyte inflammation and its low circulating pre-operative concentrations predict worse type 2 diabetes remission after bariatric surgery in obese patients". Journal of Clinical Medicine. 8 (4), 2019, 479 | es_ES |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62218 | - |
dc.description.abstract | Objective: Glucagon-like peptide (GLP)-1 has been proposed as a key candidate in glucose improvements after bariatric surgery. Our aim was to explore the role of GLP-1 in surgically-induced type 2 diabetes (T2D) improvement and its capacity to regulate human adipocyte inflammation. Methods: Basal circulating concentrations of GLP-1 as well as during an oral glucose tolerance test (OGTT) were measured in lean and obese volunteers with and without T2D (n = 93). In addition, GLP-1 levels were determined before and after weight loss achieved by Roux-en-Y gastric bypass (RYGB) (n = 77). The impact of GLP-1 on inflammation signalling pathways was also evaluated. Results: We show that the reduced (p < 0.05) circulating levels of GLP-1 in obese T2D patients increased (p < 0.05) after RYGB. The area under the curve was significantly lower in obese patients with (p < 0.01) and without (p < 0.05) T2D compared to lean volunteers while obese patients with T2D exhibited decreased GLP-1 levels at baseline (p < 0.05) and 120 min (p < 0.01) after the OGTT. Importantly, higher (p < 0.05) pre-operative GLP-1 concentrations were found in patients with T2D remission after RYGB. We also revealed that exendin-4, a GLP-1 agonist, downregulated the expression of inflammation-related genes (IL1B, IL6, IL8, TNF) and, conversely, upregulated the mRNA levels of ADIPOQ in human visceral adipocytes. Furthermore, exendin-4 blocked (p < 0.05) LPS-induced inflammation in human adipocytes via downregulating the expression and secretion of key inflammatory markers. Conclusions: Our data indicate that GLP-1 may contribute to glycemic control and exert a role in T2D remission after RYGB. GLP-1 is also involved in limiting inflammation in human visceral adipocytes. | es_ES |
dc.description.sponsorship | This work was supported by ISCIII-Subdirección General de Evaluación y FEDER (PI16/01217, PI17/02183 and PI17/02188; Plan Estatal I + D + I) and by the Gobierno de Navarra (10/2018). CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the ISCIII, Spain | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | GLP-1 | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Adipose tissue | es_ES |
dc.subject | Bariatric surgery | es_ES |
dc.subject | T2D remission | es_ES |
dc.title | GLP-1 limits adipocyte inflammation and its low circulating pre-operative concentrations predict worse type 2 diabetes remission after bariatric surgery in obese patients | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited | es_ES |
dc.identifier.doi | 10.3390/jcm8040479 | - |
dadun.citation.number | 4 | es_ES |
dadun.citation.publicationName | Journal of Clinical Medicine | es_ES |
dadun.citation.startingPage | 479 | es_ES |
dadun.citation.volume | 8 | es_ES |
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