Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Ajona, D. (Daniel) | - |
dc.creator | Ortiz-Espinosa, S. (Sergio) | - |
dc.creator | Pio, R. (Rubén) | - |
dc.creator | Lecanda, F. (Fernando) | - |
dc.date.accessioned | 2021-11-04T08:28:20Z | - |
dc.date.available | 2021-11-04T08:28:20Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Ajona, D. (Daniel); Ortiz-Espinosa, S. (Sergio); Pio, R. (Rubén); et al. "Complement in metastasis: a comp in the camp". Frontiers in Immunology. 10, 2019, 669 | es_ES |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62314 | - |
dc.description.abstract | The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep process of metastasis entails the acquisition of advantageous functions required for the formation of secondary tumors. Thus, targeting components of the complement system could impact not only on tumor initiation but also on several crucial steps along tumor dissemination. This novel vulnerability could be concomitantly exploited with current strategies overcoming tumor-mediated immunosuppression to provide a substantial clinical benefit in the treatment of metastatic disease. In this review, we offer a tour d’horizon on recent advances in this area and their prospective potential for cancer treatment. | es_ES |
dc.description.sponsorship | Authors’ work is supported by FIMA (Foundation for Applied Medical Research), and CIBERONC (CB16/12/00443). DA and RP are funded by Fundación Científica de la Asociación Española Contra el Cáncer, Fundación Ramón Areces, Juan Serrano, and Fondo de Investigación Sanitaria-Fondo Europeo de Desarrollo Regional Una manera de hacer Europa (FEDER, PI17/00411). FL is funded by La Caixa Foundation, Caja Navarra Foundation and the Spanish Ministry of Economy and Competitiveness (SAF2015-71606R). SO-E was supported by a predoctoral fellowship from the Asociación de Amigos de la Universidad de Navarra and now is supported by an FPU fellowship. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media SA | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | Metastasis | es_ES |
dc.subject | Complement | es_ES |
dc.subject | Tumor microenvironment | es_ES |
dc.subject | Anaphylatoxin | es_ES |
dc.subject | Bone colonization | es_ES |
dc.title | Complement in metastasis: a comp in the camp | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) | es_ES |
dc.identifier.doi | 10.3389/fimmu.2019.00669 | - |
dadun.citation.publicationName | Frontiers in Immunology | es_ES |
dadun.citation.startingPage | 669 | es_ES |
dadun.citation.volume | 10 | es_ES |
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