Full metadata record
DC Field | Value | Language |
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dc.creator | Martinez-Velez, N. (Naiara) | - |
dc.creator | Garcia-Moure, M. (Marc) | - |
dc.creator | Marigil, M. (Miguel) | - |
dc.creator | Gonzalez-Huarriz, M. (Marisol) | - |
dc.creator | Puigdelloses-Vallcorba, M. (Montserrat) | - |
dc.creator | Gallego-Perez-Larraya, J. (Jaime) | - |
dc.creator | Zalacain, M. (Marta) | - |
dc.creator | Marrodán, L. (Lucía) | - |
dc.creator | Varela-Guruceaga, M. (Maider) | - |
dc.creator | Laspidea, V. (Virginia) | - |
dc.creator | Aristu-Mendioroz, J.J. (José Javier) | - |
dc.creator | Ramos, L.I. (Luis Isaac) | - |
dc.creator | Tejada-Solis, S. (Sonia) | - |
dc.creator | Diez-Valle, R. (Ricardo) | - |
dc.creator | Jones, C. (Chris) | - |
dc.creator | Mackay, A. (Alan) | - |
dc.creator | Martinez-Climent, J.A. (José Ángel) | - |
dc.creator | García-Barchino, M.J. (María José) | - |
dc.creator | Raabe, E. (Eric) | - |
dc.creator | Monje, M. (Michelle) | - |
dc.creator | Becher, O.J. (Oren J.) | - |
dc.creator | Junier, M.P. (Marie Pierre) | - |
dc.creator | El-Habr, E. (Elías) | - |
dc.creator | Chneiweiss, H. (Hervé) | - |
dc.creator | Aldave, G. (Guillermo) | - |
dc.creator | Jiang, H. (Hong) | - |
dc.creator | Fueyo, J. (Juan) | - |
dc.creator | Patiño-García, A. (Ana) | - |
dc.creator | Gomez-Manzano, C. (Candelaria) | - |
dc.creator | Alonso-Roldán, M.M. (Marta María) | - |
dc.date.accessioned | 2021-11-09T11:24:01Z | - |
dc.date.available | 2021-11-09T11:24:01Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Martinez-Velez, N. (Naiara); Garcia-Moure, M. (Marc); Marigil, M. (Miguel); et al. "The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models". Nature Communications. 10 (2235), 2019, 1 - 10 | es |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | PMID: 31138805 | - |
dc.identifier.uri | https://hdl.handle.net/10171/62393 | - |
dc.description.abstract | Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic virotherapy is emerging as a solid therapeutic approach. Delta-24-RGD is a replication competent adenovirus engineered to replicate in tumor cells with an aberrant RB pathway. This virus has proven to be safe and effective in adult gliomas. Here we report that the administration of Delta-24-RGD is safe in mice and results in a significant increase in survival in immunodeficient and immunocompetent models of pHGG and DIPGs. Our results show that the Delta-24-RGD antiglioma effect is mediated by the oncolytic effect and the immune response elicited against the tumor. Altogether, our data highlight the potential of this virus as treatment for patients with these tumors. Of clinical significance, these data have led to the start of a phase I/II clinical trial at our institution for newly diagnosed DIPG (NCT03178032). | es_ES |
dc.description.sponsorship | This work was supported by the European Union (Marie Curie IRG270459; to M.M. Alonso), the Instituto de Salud Carlos III y los Fondos Feder Europeos (PI13/125; PI16/0066 to M.M. Alonso), the Spanish Ministry of Science and Innovation (Ramón y Cajal contract RYC-2009–05571, IEDI-2015-00638, and BIO2015-68990-REDT to M.M. Alonso), the Department of Health of the Government of Navarra (to M.M. Alonso), the Basque Foundation for Health Research (BIOEF, BIO13/CI/005), Foundation LA CAIXA/Caja Navarra (A-PG, MMA), Foundation “El sueño de Vicky”, Asociation Pablo Ugarte-Fuerza Julen (A-PG,MMA), and DOD team science award (MMA, JF, and CG-M). The Cancer Prevention and Research Institute of Texas (RP170066; C-GM and JF, the Rory David Deutsch Foundation (OJB) and Instituto de Salud Carlos III—CIBERONC (to JAM-C and MJG-B). This project has received funding from the European Research Council (ERC) under the European Union´s Horizon 2020 research and innovation programme (grant agreement No. 817884; ViroPedTher). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Science and Business Media LLC | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/817884/EU | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Oncología | es_ES |
dc.title | The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | es_ES |
dc.identifier.doi | 10.1038/s41467-019-10043-0 | - |
dadun.citation.endingPage | 10 | es_ES |
dadun.citation.number | 2235 | es_ES |
dadun.citation.publicationName | Nature Communications | es_ES |
dadun.citation.startingPage | 1 | es_ES |
dadun.citation.volume | 10 | es_ES |
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