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Campo DC | Valor | Lengua/Idioma |
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dc.creator | Ramos-Campoy, S. (Silvia) | - |
dc.creator | Puiggros, A. (Anna) | - |
dc.creator | Bea, S. (Silvia) | - |
dc.creator | Bougeon, S. (Sandrine) | - |
dc.creator | Larrayoz, M.J. (María J.) | - |
dc.creator | Costa, D. (Dolors) | - |
dc.creator | Parker, H. (Helen) | - |
dc.creator | Rigolin, G.M. (Gian Matteo) | - |
dc.creator | Ortega, M. (Margarita) | - |
dc.creator | Blanco, M.L. (María Laura) | - |
dc.creator | Collado, R. (Rosa) | - |
dc.creator | Salgado, R. (Rocío) | - |
dc.creator | Baumann, T. (Tycho) | - |
dc.creator | Gimeno, E. (Eva) | - |
dc.creator | Moreno, C. (Carolina) | - |
dc.creator | Bosch, F. (Francesc) | - |
dc.creator | Calvo, X. (Xavier) | - |
dc.creator | Calasanz-Abinzano, M.J. (Maria Jose) | - |
dc.creator | Cuneo, A. (Antonio) | - |
dc.creator | Strefford, J.C. (Jonathan C.) | - |
dc.creator | Nguyen-Khac, F. (Florence) | - |
dc.creator | Oscier, D. (David) | - |
dc.creator | Haferlach, C. (Claudia) | - |
dc.creator | Schoumans, J. (Jacqueline) | - |
dc.creator | Espinet, B. (Blanca) | - |
dc.date.accessioned | 2022-03-14T13:45:00Z | - |
dc.date.available | 2022-03-14T13:45:00Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Ramos-Campoy, S.; Puiggros, A.; Bea, S.; et al. "Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients". Haematologica. 107 (3), 2022, 593 - 603 | es |
dc.identifier.issn | 1592-8721 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63172 | - |
dc.description.abstract | Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL patients highly enriched in cases with complex karyotype (CK) (46.5%) with parallel CBA and GM studies. Abnormalities found by both techniques were compared. Prognostic stratification in three risk groups based on genomic complexity (0-2, 3- 4 and ¿5 abnormalities) was also analyzed. No significant differences in the percentage of patients in each group were detected, but only a moderate agreement was observed between methods when focusing on individual cases (kappa=0.507; P<0.001). Discordant classification was obtained in 100 patients (29.4%), including 3% classified in opposite risk groups. Most discrepancies were technique-dependent and no greater correlation in the number of abnormalities was achieved when different filtering strategies were applied for GM. Nonetheless, both methods showed a similar concordance index for prediction of time to first treatment (TTFT) (CBA: 0.67 vs. GM: 0.65) and overall survival (CBA: 0.55 vs. GM: 0.57). | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Área de Biomedicina | - |
dc.title | Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | https://creativecommons.org/licenses/by-nc/4.0/l | - |
dc.identifier.doi | 10.3324/haematol.2020.274456 | - |
dadun.citation.endingPage | 603 | - |
dadun.citation.number | 3 | - |
dadun.citation.publicationName | Haematologica | - |
dadun.citation.startingPage | 593 | - |
dadun.citation.volume | 107 | - |
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