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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Rodriguez-Nogales, C. (Carlos) | - |
dc.creator | Sebastian, V. (Víctor) | - |
dc.creator | Blanco-Prieto, M.J. (María José) | - |
dc.creator | Couvreur, P. (Patrick) | - |
dc.creator | Desmaële, D. (Didier) | - |
dc.date.accessioned | 2022-04-05T08:43:10Z | - |
dc.date.available | 2022-04-05T08:43:10Z | - |
dc.date.issued | 2021-12-14 | - |
dc.identifier.citation | Rodriguez-Nogales, C. (Carlos); Sebastian, V. (Víctor); Blanco-Prieto, M.J. (María José); et al. "Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors". ChemMedChem. 16 (24), 2021-12-14, 3730 - 3738 | es_ES |
dc.identifier.issn | 1860-7179 | - |
dc.identifier.uri | https://hdl.handle.net/10171/63341 | - |
dc.description.abstract | Therapeutic perspectives of bone tumors such as osteosarcom are main restricted due to the inefficacy of current treatments. We propose here the construction of a novel anticancers qualene-based nanomedicine with bone affinity and retention capacity. A squalenyl-hydroxybisphosphonate molecule was synthetized by chemical conjugation of a 1-hydroxyl-1,1-bi-sphosphonatemoiety to the squalenechain. This amphiphilic compound was inserted onto squalenoyl-gemcitabinenano-particles using the nanoprecipitation method. The co-assemblyled to nanoconstructsof 75 nm, with different morphology and colloidal properties. The presence of squalenyl-hydroxybi-sphosphonate enhanced the nanoparticles binding affinity for hydroxyapatite,a mineral present in the bone. Moreover, the in vitro anticancer activity was preserved when tested in commercial and patient-treated derived pedia tricoste osarcomacells. Furtherin vivo studies will shed lighton the potential of these nano medicines for the treatment of bones arcomas. | es_ES |
dc.description.sponsorship | Asociación Española Contra el Cáncer (AECC) (CI14142069BLAN), Fundación Caja Navarra/Obra Social La Caixa and the Asociación de familiares y amigos de pacientes con neuroblastoma (NEN, Nico contra el cáncer) are gratefully acknowledged. CIBER-BBN is an initiative funded by the VI Spanish National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, Consolider Program, CIBERActions and financed by the Instituto de Salud Carlos III (Spain) with assistance from the European Regional Development Fund. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Osteosarcome | es_ES |
dc.subject | Antitumor agents | es_ES |
dc.subject | Nanoparticles | es_ES |
dc.subject | Hydroxyapatite | es_ES |
dc.title | Decoration of squalenoyl-gemcitabine nanoparticles with squalenyl-hydroxybisphosphonate for the treatment of bone tumors | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the terms of the Creative Commons Attribution Non-Commercial No Derivs License | es_ES |
dc.identifier.doi | 10.1002/cmdc.202100464 | - |
dadun.citation.endingPage | 3738 | es_ES |
dadun.citation.number | 24 | es_ES |
dadun.citation.publicationName | ChemMedChem | es_ES |
dadun.citation.startingPage | 3730 | es_ES |
dadun.citation.volume | 16 | es_ES |
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