DADUN: Interleukin-12 message in a bottle

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Interleukin-12 message in a bottle

Authors:

Cirella, A. (Assunta)

Berraondo, P. (Pedro)

Di-Trani, C.A. (Claudia Augusta)

Melero, I. (Ignacio)

Keywords:

Interleukin-12
Immunotherapy
Lipid-nanoparticle mRNA

Issue Date:

2020

Publisher:

American Association for Cancer Research

Project:

765394 - Tumor-Treg-Targeting - Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours
635122 - PROCROP - Professional cross-priming for ovary and prostate cancer
643638 - TRANSCAN-2 - ERA-NET: Aligning national/regional translational cancer research programmes and activities

ISSN:

1078-0432

Citation:

Cirella, A. (Assunta); Berraondo, P. (Pedro); Di-Trani, C.A. (Carla Augusta); et al. "Interleukin-12 message in a bottle". Clinical cancer research. 26 (23), 2020, 6080 - 6082

Abstract

IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.

URI:

https://hdl.handle.net/10171/63353

DOI:

10.1158/1078-0432.CCR-20-3250

Appears in Collections:

DA - CIMA - Inmunología e inmunoterapia - Inmunoterapia - Artículos de Revista

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