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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Cirella, A. (Assunta) | - |
| dc.creator | Berraondo, P. (Pedro) | - |
| dc.creator | Di-Trani, C.A. (Claudia Augusta) | - |
| dc.creator | Melero, I. (Ignacio) | - |
| dc.date.accessioned | 2022-04-06T07:45:36Z | - |
| dc.date.available | 2022-04-06T07:45:36Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.citation | Cirella, A. (Assunta); Berraondo, P. (Pedro); Di-Trani, C.A. (Carla Augusta); et al. "Interleukin-12 message in a bottle". Clinical cancer research. 26 (23), 2020, 6080 - 6082 | es |
| dc.identifier.issn | 1078-0432 | - |
| dc.identifier.other | 33004432 | - |
| dc.identifier.uri | https://hdl.handle.net/10171/63353 | - |
| dc.description.abstract | IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial. | es_ES |
| dc.description.sponsorship | This work was supported by European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no 765394, Spanish Ministry of Economy and Competitiveness (MINECO SAF 2017–83267-C2–1R [AEI/FEDER, UE]), Cancer Research Institute (CRI), Asociación Española Contra el Cancer (AECC) Foundation under Grant GCB15152947MELE, H2020 PROCROP project under Grant 635122, Instituto de Salud Carlos III (PI19/01128) cofinanced by Fondos Feder and Joint Translational Call for Proposals 2015 (JTC 2015) TRANSCAN-2 (code: TRS-2016–00000371). | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | American Association for Cancer Research | es_ES |
| dc.relation | info:eu-repo/grantAgreement/EC/H2020/765394/EU | es_ES |
| dc.relation | info:eu-repo/grantAgreement/EC/H2020/635122/EU | - |
| dc.relation | info:eu-repo/grantAgreement/EC/H2020/643638/EU | - |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.subject | Interleukin-12 | es_ES |
| dc.subject | Immunotherapy | es_ES |
| dc.subject | Lipid-nanoparticle mRNA | es_ES |
| dc.title | Interleukin-12 message in a bottle | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.identifier.doi | 10.1158/1078-0432.CCR-20-3250 | - |
| dadun.citation.number | 23 | es_ES |
| dadun.citation.publicationName | Clinical cancer research | es_ES |
| dadun.citation.startingPage | 6080 | es_ES |
| dadun.citation.volume | 26 | es_ES |
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