Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe
Keywords: 
Consensus
Statement
Screening
Lung cancer
Mortality
Reduction
Low dose
Computed tomography
Implementation
Issue Date: 
2020
Publisher: 
MDPI AG
ISSN: 
2072-6694
Note: 
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Citation: 
Veronesi, G. (Giulia); Baldwin, D.R. (David R.); Henschke, C.I. (C.I.); et al. "Recommendations for implementing lung cancer screening with low-dose computed tomography in Europe". Cancers. 12 (6), 2020, 1672
Abstract
Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

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